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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Purine studies. XVII. The synthesis of 2-substituted 6,9-Di- and 6,8,9-Tri-methylpurines as amplifiers of phleomycin

K Bhushan, DJ Brown, JH Lister, LG Stephanson and F Yoneda

Australian Journal of Chemistry 28(11) 2553 - 2559
Published: 1975

Abstract

2-(6?,8?,9?-Trimethylpurin-2?-ylthio)acetamide (1e) and analogous N- substituted acetamides are prepared by treatment of 6,8,9- trimethylpurine-2-thione (3a) with an appropriate 2- chloroacetamide. 6,9-Dimethyl-2-(piperidin-1?-yl)purine (In) and some 2- polymethyleneamino homologues are made by initial amination of 2- chloro-4-methyl-6-methylamino-5-nitropyrimidine (2b) followed by reduction of the nitro group and final cyclization with formic acid. Such purines enhance the lethal effect of phleomycin on Escherichia coli cultures.

https://doi.org/10.1071/CH9752553

© CSIRO 1975

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