Acridone studies. XII. Relative rates of reaction of sodium methoxide with 1,2,3,4-Tetramethoxy-10-methylacridone

Abstract

The relative and absolute rates of exchange of the four methoxyl groups in 1,2,3,4-tetramethoxy-10methylacridone (melicopicine) have been measured at 50º. The reaction at C1 is more than 15 times faster than at C3. These rates of reaction are compared with those of 1,4-dimethoxy-l0-methyl-2,3-methylenedioxyacridone (melicopidine), and suggestions made to account for the differences.