Acridone studies. VI. Bromination of acridones in chloroform

Abstract

In chloroform and acetic acid, N-methylacridone and methoxylated derivatives rapidly form 1 : 2 adducts with bromine, formulated as hypobromite salts. On gentle warming these decompose to the monobromo substitution product. Hydroxylated acridones appear to also add bromine to the substituted ring, forming products which are highly reactive to water and other nucleophiles.