The synthesis and chemistry of DL-Indoline-2-carboxylic acid

Abstract

Indole-2-carboxamide is reduced by phosphonium iodide and fuming hydriodic acid to DL-indoline-2-carboxamide, hydrolysis of which readily gives indoline-2-carboxylic acid. The chemistry of this new amino acid and some of its derivatives has been explored. Benzimidazole-2-carboxamide is inert to phosphonium iodide/hydriodic acid.