Stereochemistry of Cyclohexane Derivatives. VII. The 4-Aminocyclohexanols

Abstract

The structures assigned to the 4-aminocyclohexanols have been confirmed and some fundamental reactions studied. Solvolysis of trans-4-benzamidocyclohexyl toluene-p-sulphonate has shown absence of participation in the rate-determining step although product analysis indicates that the reaction proceeds with retention of configuration. The bromination of 4-benzamidocyclohexene and solvolysis of the products have been studied.