Synthetic antispasmodics. II. Some acyclic analogues of papaverine

Abstract

The preparation is described of four series of open-chain analogues of papaverine : N-alkyl-α-aminodeoxyanisoins, N-alkyl-2-amino-1,2-di-(p-methoxyphenyl)-ethanols, N-alkyl-1,2-di-(p-methoxyphenyl)ethylamines, and N-alkyl-di-(p-methoxyphenyl)methylamines. All of these showed spasmolytic activity and considerably lower toxicity than papaverine.