N,N-Dimethylformamide dimethyl acetal (DMFDMA): from derivatisation to C1 synthon
Natalie Ferreira Araujo
A * and Sabrina Baptista Ferreira A
A
Abstract
N,N-Dimethylformamide dimethyl acetal (DMFDMA), also called 1,1-dimethoxy-N,N-dimethylmethanamine, is a colorless liquid with rancid odour. The chemical structure of DMFDMA presents two important sites, a partially positive carbon that acts as an electrophile in condensation reactions and a partially negative nitrogen that acts as a nucleophile. Because of its structure, DMFDMA reacts with many different organic groups and can be a versatile reagent used in gas chromatography, as a protecting group and as a C1 synthon, especially in the construction of heterocycles.
Keywords: alkylating agent, C1 synthon, enaminone synthesis, gas chromatography, heterocyclic synthesis, N,N-dimethylformamide dimethyl acetal, protecting group, selective alkyl cleavage.
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