Nanomedicine-based modulation of redox status for cancer therapy
Ping Jin A # , Lei Li B # , Edouard Collins Nice C * and Canhua Huang
A *
+ Author Affiliations
- Author Affiliations
A State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, 610041, P. R. China.
B School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
C Department of Biochemistry and Molecular Biology, Monash University, Clayton, Vic. 3800, Australia.
* Correspondence to: ed.nice@monash.edu, hcanhua@hotmail.com
# These authors contributed equally to this paper
Handling Editor: Mibel Aguilar
Australian Journal of Chemistry 76(8) 337-350 https://doi.org/10.1071/CH22246
Submitted: 24 November 2022 Accepted: 20 February 2023 Published: 2 May 2023
© 2023 The Author(s) (or their employer(s)). Published by CSIRO Publishing.
Abstract
Cancer has always been a major disease with an unfavorable impact on human health worldwide. Redox biology has a close and complicated relationship to the initiation and progression of cancer. Continuous work is being conducted to develop novel approaches for cancer prevention and therapy by modulating redox homeostasis, but problems in drug targeting, drug resistance, adverse effects and recurrence are persistent challenges. Nanotechnology is emerging as a powerful tool to achieve specific targeting, non-invasive therapeutics, high therapeutic efficiency and improved drug sensitivity for cancers by exploiting the features of their microenvironment, especially the redox properties. In addition, nanoplatform-mediated delivery of anticancer drugs or exogenous antioxidants/oxidants affords a promising prospect for cancer therapy. In this review, we will summarize recent advances in redox species-responsive nanoplatforms for tumor treatment. Current nanocarrier mediated strategies that manage redox status for cancer treatment will also be discussed.
Keywords: antioxidants, chemodynamic therapy (CDT), GSH‐responsive nanoplatforms, H2O2‐responsive theranostics, nanotechnology, redox, tumor, tumor microenvironment.
References
[1] JD Hayes, AT Dinkova-Kostova, KD Tew, Oxidative stress in cancer. Cancer Cell 2020, 38, 167.| Oxidative stress in cancer.Crossref | GoogleScholarGoogle Scholar |
[2] Y Nie, W Chen, Y Kang, X Yuan, Y Li, J Zhou, et al. Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy. Biomaterials. 2023, 295, 122031.
| Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy.Crossref | GoogleScholarGoogle Scholar |
[3] B Li, C Sun, X Lin, W Busch, The emerging role of GSNOR in oxidative stress regulation. Trends Plant Sci 2021, 26, 156.
| The emerging role of GSNOR in oxidative stress regulation.Crossref | GoogleScholarGoogle Scholar |
[4] J Morry, W Ngamcherdtrakul, W Yantasee, Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles. Redox Biol 2017, 11, 240.
| Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles.Crossref | GoogleScholarGoogle Scholar |
[5] J Jiang, L Peng, K Wang, C Huang, Moonlighting metabolic enzymes in cancer: New perspectives on the redox code. Antioxid Redox Signal 2021, 34, 979.
| Moonlighting metabolic enzymes in cancer: New perspectives on the redox code.Crossref | GoogleScholarGoogle Scholar |
[6] (a) L Zuo, D Wijegunawardana, Redox role of ROS and inflammation in pulmonary diseases. In: Wang YX, editor. Lung inflammation in health and disease, Vol. II. Advances in experimental medicine and biology. Vol. 1304. Cham: Springer; 2021. pp. 187–204.
(b) P Żukowski, M Maciejczyk, D Waszkiel, Sources of free radicals and oxidative stress in the oral cavity. Arch Oral Biol 2018, 92, 8.
| Sources of free radicals and oxidative stress in the oral cavity.Crossref | GoogleScholarGoogle Scholar |
[7] Y-p Zhu, Z Zheng, S Hu, X Ru, Z Fan, L Qiu, et al. Unification of opposites between two antioxidant transcription factors Nrf1 and Nrf2 in mediating distinct cellular responses to the endoplasmic reticulum stressor tunicamycin. Antioxidants (Basel) 2019, 9, 4.
| Unification of opposites between two antioxidant transcription factors Nrf1 and Nrf2 in mediating distinct cellular responses to the endoplasmic reticulum stressor tunicamycin.Crossref | GoogleScholarGoogle Scholar |
[8] (a) Z Iqbal, A Sarkhosh, RM Balal, C Gómez, M Zubair, N Ilyas, et al. Silicon alleviate hypoxia stress by improving enzymatic and non-enzymatic antioxidants and regulating nutrient uptake in muscadine grape (Muscadinia rotundifolia Michx.). Front Plant Sci 2020, 11, 618873.
| Silicon alleviate hypoxia stress by improving enzymatic and non-enzymatic antioxidants and regulating nutrient uptake in muscadine grape (Muscadinia rotundifolia Michx.).Crossref | GoogleScholarGoogle Scholar |
(b) S Casagrande, M Hau, Enzymatic antioxidants but not baseline glucocorticoids mediate the reproduction–survival trade-off in a wild bird. Proc Biol Sci 2018, 285, 20182141.
| Enzymatic antioxidants but not baseline glucocorticoids mediate the reproduction–survival trade-off in a wild bird.Crossref | GoogleScholarGoogle Scholar |
[9] W Xiao, J Loscalzo, Metabolic responses to reductive stress. Antioxid Redox Signal 2020, 32, 1330.
| Metabolic responses to reductive stress.Crossref | GoogleScholarGoogle Scholar |
[10] L Peng, J Jiang, H-N Chen, L Zhou, Z Huang, S Qin, et al. Redox-sensitive cyclophilin a elicits chemoresistance through realigning cellular oxidative status in colorectal cancer. Cell Rep 2021, 37, 110069.
| Redox-sensitive cyclophilin a elicits chemoresistance through realigning cellular oxidative status in colorectal cancer.Crossref | GoogleScholarGoogle Scholar |
[11] JE Klaunig, Oxidative stress and cancer. Curr Pharm Des 2018, 24, 4771.
| Oxidative stress and cancer.Crossref | GoogleScholarGoogle Scholar |
[12] J Xu, S Zhang, R Wang, X Wu, L Zeng, Z Fu, Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway. Biosci Rep 2017, 37, BSR20160447.
| Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway.Crossref | GoogleScholarGoogle Scholar |
[13] Y Sun, N Berleth, W Wu, D Schlütermann, J Deitersen, F Stuhldreier, et al. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Cell Death Dis 2021, 12, 1028.
| Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.Crossref | GoogleScholarGoogle Scholar |
[14] M Azmanova, A Pitto-Barry, Oxidative stress in cancer therapy: Friend or enemy? Chembiochem. 2022, 23, e202100641.
| Oxidative stress in cancer therapy: Friend or enemy?Crossref | GoogleScholarGoogle Scholar |
[15] AE Albalawi , AD Alanazi , P Baharvand , M Sepahvand , H Mahmoudvand , High Potency of Organic and Inorganic Nanoparticles to Treat Cystic Echinococcosis: An Evidence-Based Review. Nanomaterials (Basel) 2020, 10,
| High Potency of Organic and Inorganic Nanoparticles to Treat Cystic Echinococcosis: An Evidence-Based Review.Crossref | GoogleScholarGoogle Scholar |
[16] W Liu , J Su , Q Shi , J Wang , X Chen , S Zhang , M Li , J Cui , C Fan , B Sun , G Wang , RGD Peptide-Conjugated Selenium Nanocomposite Inhibits Human Glioma Growth by Triggering Mitochondrial Dysfunction and ROS-Dependent MAPKs Activation. Front Bioeng Biotechnol 2021, 9, 781608.
| RGD Peptide-Conjugated Selenium Nanocomposite Inhibits Human Glioma Growth by Triggering Mitochondrial Dysfunction and ROS-Dependent MAPKs Activation.Crossref | GoogleScholarGoogle Scholar |
[17] (a) M Yang, J Li, P Gu, X Fan, The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment. Bioact Mater 2021, 6, 1973.
| The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment.Crossref | GoogleScholarGoogle Scholar |
(b) C Roma-Rodrigues, R Mendes, PV Baptista, AR Fernandes, Targeting tumor microenvironment for cancer therapy. Int J Mol Sci 2019, 20, 840.
| Targeting tumor microenvironment for cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[18] M Chen, D Liu, F Liu, Y Wu, X Peng, F Song, Recent advances of redox-responsive nanoplatforms for tumor theranostics. J Control Release 2021, 332, 269.
| Recent advances of redox-responsive nanoplatforms for tumor theranostics.Crossref | GoogleScholarGoogle Scholar |
[19] H Tian, T Zhang, S Qin, Z Huang, L Zhou, J Shi, et al. Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies J Hematol Oncol 2022, 15, 132.
| Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategiesCrossref | GoogleScholarGoogle Scholar |
[20] X-Y Li, F-A Deng, R-R Zheng, L-S Liu, Y-B Liu, R-J Kong, et al. Carrier free photodynamic synergists for oxidative damage amplified tumor therapy. Small. 2021, 17, e2102470.
| Carrier free photodynamic synergists for oxidative damage amplified tumor therapy.Crossref | GoogleScholarGoogle Scholar |
[21] T Chen, W Zeng, C Tie, M Yu, H Hao, Y Deng, et al. Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics. Bioact Mater 2022, 10, 515.
| Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics.Crossref | GoogleScholarGoogle Scholar |
[22] JL Quiles, C Sánchez-González, L Vera-Ramírez, F Giampieri, MD Navarro-Hortal, J Xiao, et al. Reductive stress, bioactive compounds, redox-active metals, and dormant tumor cell biology to develop redox-based tools for the treatment of cancer. Antioxid Redox Signal 2020, 33, 860.
| Reductive stress, bioactive compounds, redox-active metals, and dormant tumor cell biology to develop redox-based tools for the treatment of cancer.Crossref | GoogleScholarGoogle Scholar |
[23] (a) G-R Tan, C-YS Hsu, Y Zhang, pH-responsive hybrid nanoparticles for imaging spatiotemporal pH changes in biofilm-dentin microenvironments. ACS Appl Mater Interfaces 2021, 13, 46247.
| pH-responsive hybrid nanoparticles for imaging spatiotemporal pH changes in biofilm-dentin microenvironments.Crossref | GoogleScholarGoogle Scholar |
(b) N Xie, G Shen, W Gao, Z Huang, C Huang, L Fu, Neoantigens: Promising targets for cancer therapy. Signal Transduct Target Ther 2023, 8, 9.
| Neoantigens: Promising targets for cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[24] L Ge, C Qiao, Y Tang, X Zhang, X Jiang, Light-activated hypoxia-sensitive covalent organic framework for tandem-responsive drug delivery. Nano Lett 2021, 21, 3218.
| Light-activated hypoxia-sensitive covalent organic framework for tandem-responsive drug delivery.Crossref | GoogleScholarGoogle Scholar |
[25] (a) Y Li, J Jeon, JH Park, Hypoxia-responsive nanoparticles for tumor-targeted drug delivery. Cancer Lett 2020, 490, 31.
| Hypoxia-responsive nanoparticles for tumor-targeted drug delivery.Crossref | GoogleScholarGoogle Scholar |
(b) N Filipczak, U Joshi, SA Attia, I Berger Fridman, S Cohen, T Konry, et al. Hypoxia-sensitive drug delivery to tumors. J Control Release 2022, 341, 431.
| Hypoxia-sensitive drug delivery to tumors.Crossref | GoogleScholarGoogle Scholar |
[26] (a) M Gisbert-Garzarán, JC Berkmann, D Giasafaki, D Lozano, K Spyrou, M Manzano, et al. Engineered pH-responsive mesoporous carbon nanoparticles for drug delivery. ACS Appl Mater Interfaces 2020, 12, 14946.
| Engineered pH-responsive mesoporous carbon nanoparticles for drug delivery.Crossref | GoogleScholarGoogle Scholar |
(b) Y Xu, Y Zi, J Lei, X Mo, Z Shao, Y Wu, et al. pH-responsive nanoparticles based on cholesterol/imidazole modified oxidized-starch for targeted anticancer drug delivery. Carbohydr Polym 2020, 233, 115858.
| pH-responsive nanoparticles based on cholesterol/imidazole modified oxidized-starch for targeted anticancer drug delivery.Crossref | GoogleScholarGoogle Scholar |
[27] B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, et al. Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy. Biomaterials. 2021, 277, 121110.
| Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy.Crossref | GoogleScholarGoogle Scholar |
[28] Q Tang, Z Cheng, N Yang, Q Li, P Wang, D Chen, et al. Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy. Biomaterials. 2019, 205, 1.
| Hydrangea-structured tumor microenvironment responsive degradable nanoplatform for hypoxic tumor multimodal imaging and therapy.Crossref | GoogleScholarGoogle Scholar |
[29] LS Lin, T Huang, J Song, XY Ou, Z Wang, H Deng, et al. Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy. J Am Chem Soc 2019, 141, 9937.
| Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy.Crossref | GoogleScholarGoogle Scholar |
[30] X Wang, X Wang, S Jin, N Muhammad, Z Guo, Stimuli-responsive therapeutic metallodrugs. Chem Rev 2019, 119, 1138.
| Stimuli-responsive therapeutic metallodrugs.Crossref | GoogleScholarGoogle Scholar |
[31] X Ling, J Tu, J Wang, A Shajii, N Kong, C Feng, et al. Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy. ACS Nano 2019, 13, 357.
| Glutathione-responsive prodrug nanoparticles for effective drug delivery and cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[32] N Gong, X Ma, X Ye, Q Zhou, X Chen, X Tan, et al. Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment. Nat Nanotechnol 2019, 14, 379.
| Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment.Crossref | GoogleScholarGoogle Scholar |
[33] C Liu, D Wang, S Zhang, Y Cheng, F Yang, Y Xing, et al. Biodegradable biomimic copper/manganese silicate nanospheres for chemodynamic/photodynamic synergistic therapy with simultaneous glutathione depletion and hypoxia relief. ACS Nano 2019, 13, 4267.
| Biodegradable biomimic copper/manganese silicate nanospheres for chemodynamic/photodynamic synergistic therapy with simultaneous glutathione depletion and hypoxia relief.Crossref | GoogleScholarGoogle Scholar |
[34] Y Wang, Y Li, Z Zhang, L Wang, D Wang, BZ Tang, Triple-jump photodynamic theranostics: MnO2 combined upconversion nanoplatforms involving a type-I photosensitizer with aggregation-induced emission characteristics for potent cancer treatment. Adv Mater 2021, 33, e2103748.
| Triple-jump photodynamic theranostics: MnO2 combined upconversion nanoplatforms involving a type-I photosensitizer with aggregation-induced emission characteristics for potent cancer treatment.Crossref | GoogleScholarGoogle Scholar |
[35] Y Fan, P Li, B Hu, T Liu, Z Huang, C Shan, et al. A smart photosensitizer-cerium oxide nanoprobe for highly selective and efficient photodynamic therapy. Inorg Chem 2019, 58, 7295.
| A smart photosensitizer-cerium oxide nanoprobe for highly selective and efficient photodynamic therapy.Crossref | GoogleScholarGoogle Scholar |
[36] Y Kuang, K Balakrishnan, V Gandhi, X Peng, Hydrogen peroxide inducible DNA cross-linking agents: Targeted anticancer prodrugs. J Am Chem Soc 2011, 133, 19278.
| Hydrogen peroxide inducible DNA cross-linking agents: Targeted anticancer prodrugs.Crossref | GoogleScholarGoogle Scholar |
[37] P Guo, K Wang, W-J Jin, H Xie, L Qi, X-Y Liu, et al. Dynamic kinetic cross-electrophile arylation of benzyl alcohols by nickel catalysis. J Am Chem Soc 2021, 143, 513.
| Dynamic kinetic cross-electrophile arylation of benzyl alcohols by nickel catalysis.Crossref | GoogleScholarGoogle Scholar |
[38] S Sun, Q Chen, Z Tang, C Liu, Z Li, A Wu, et al. Tumor microenvironment stimuli-responsive fluorescence imaging and synergistic cancer therapy by carbon-dot–Cu2+ nanoassemblies. Angew Chem Int Ed Engl 2020, 59, 21041.
| Tumor microenvironment stimuli-responsive fluorescence imaging and synergistic cancer therapy by carbon-dot–Cu2+ nanoassemblies.Crossref | GoogleScholarGoogle Scholar |
[39] H Ding, Y Cai, L Gao, M Liang, B Miao, H Wu, et al. Exosome-like nanozyme vesicles for H2O2-responsive catalytic photoacoustic imaging of xenograft nasopharyngeal carcinoma. Nano Lett 2019, 19, 203.
| Exosome-like nanozyme vesicles for H2O2-responsive catalytic photoacoustic imaging of xenograft nasopharyngeal carcinoma.Crossref | GoogleScholarGoogle Scholar |
[40] Q Zeng, R Zhang, T Zhang, D Xing, H2O2-responsive biodegradable nanomedicine for cancer-selective dual-modal imaging guided precise photodynamic therapy. Biomaterials. 2019, 207, 39.
| H2O2-responsive biodegradable nanomedicine for cancer-selective dual-modal imaging guided precise photodynamic therapy.Crossref | GoogleScholarGoogle Scholar |
[41] H He, S Meng, H Li, Q Yang, Z Xu, X Chen, et al. Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging. Mikrochim Acta 2021, 188, 154.
| Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging.Crossref | GoogleScholarGoogle Scholar |
[42] J Xu, W Han, Z Cheng, P Yang, H Bi, D Yang, et al. Bioresponsive and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules. Chem Sci 2018, 9, 3233.
| Bioresponsive and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules.Crossref | GoogleScholarGoogle Scholar |
[43] S Bertoni, A Machness, M Tiboni, R Bártolo, HA Santos, Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting. Biopolymers. 2020, 111, e23336.
| Reactive oxygen species responsive nanoplatforms as smart drug delivery systems for gastrointestinal tract targeting.Crossref | GoogleScholarGoogle Scholar |
[44] B Yang, K Wang, D Zhang, B Sun, B Ji, L Wei, et al. Light-activatable dual-source ROS-responsive prodrug nanoplatform for synergistic chemo-photodynamic therapy. Biomater Sci 2018, 6, 2965.
| Light-activatable dual-source ROS-responsive prodrug nanoplatform for synergistic chemo-photodynamic therapy.Crossref | GoogleScholarGoogle Scholar |
[45] HL Lee, SC Hwang, JW Nah, J Kim, B Cha, DH Kang, et al. Redox- and pH-responsive nanoparticles release piperlongumine in a stimuli-sensitive manner to inhibit pulmonary metastasis of colorectal carcinoma cells. J Pharm Sci 2018, 107, 2702.
| Redox- and pH-responsive nanoparticles release piperlongumine in a stimuli-sensitive manner to inhibit pulmonary metastasis of colorectal carcinoma cells.Crossref | GoogleScholarGoogle Scholar |
[46] A Xie, S Hanif, J Ouyang, Z Tang, N Kong, NY Kim, et al. Stimuli-responsive prodrug-based cancer nanomedicine. EBioMedicine. 2020, 56, 102821.
| Stimuli-responsive prodrug-based cancer nanomedicine.Crossref | GoogleScholarGoogle Scholar |
[47] L He, M Sun, X Cheng, Y Xu, X Lv, X Wang, et al. pH/redox dual-sensitive platinum (IV)-based micelles with greatly enhanced antitumor effect for combination chemotherapy. J Colloid Interface Sci 2019, 541, 30.
| pH/redox dual-sensitive platinum (IV)-based micelles with greatly enhanced antitumor effect for combination chemotherapy.Crossref | GoogleScholarGoogle Scholar |
[48] (a) L Han, X-Y Zhang, Y-L Wang, X Li, X-H Yang, M Huang, et al. Redox-responsive theranostic nanoplatforms based on inorganic nanomaterials. J Control Release 2017, 259, 40.
| Redox-responsive theranostic nanoplatforms based on inorganic nanomaterials.Crossref | GoogleScholarGoogle Scholar |
(b) J Yang, S Pan, S Gao, Y Dai, H Xu, Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system. Biomaterials 2020, 249, 120054.
| Anti-recurrence/metastasis and chemosensitization therapy with thioredoxin reductase-interfering drug delivery system.Crossref | GoogleScholarGoogle Scholar |
[49] Y Wang, PK Shahi, X Wang, R Xie, Y Zhao, M Wu, et al. In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles. J Control Release 2021, 336, 296.
| In vivo targeted delivery of nucleic acids and CRISPR genome editors enabled by GSH-responsive silica nanoparticles.Crossref | GoogleScholarGoogle Scholar |
[50] L Li, H Tian, Z Zhang, N Ding, K He, S Lu, et al. Carrier-free nanoplatform via evoking pyroptosis and immune response against breast cancer. ACS Appl Mater Interfaces 2023, 15, 452.
| Carrier-free nanoplatform via evoking pyroptosis and immune response against breast cancer.Crossref | GoogleScholarGoogle Scholar |
[51] (a) Z Yang, P Li, Y Chen, Q Gan, Z Feng, Y Jin, et al. Construction of pH/glutathione responsive chitosan nanoparticles by a self-assembly/self-crosslinking method for photodynamic therapy. Int J Biol Macromol 2021, 167, 46.
| Construction of pH/glutathione responsive chitosan nanoparticles by a self-assembly/self-crosslinking method for photodynamic therapy.Crossref | GoogleScholarGoogle Scholar |
(b) HM El-Shorbagy, SM Eissa, S Sabet, AA El-Ghor, Apoptosis and oxidative stress as relevant mechanisms of antitumor activity and genotoxicity of ZnO-NPs alone and in combination with N-acetyl cysteine in tumor-bearing mice. Int J Nanomedicine 2019, 14, 3911.
| Apoptosis and oxidative stress as relevant mechanisms of antitumor activity and genotoxicity of ZnO-NPs alone and in combination with N-acetyl cysteine in tumor-bearing mice.Crossref | GoogleScholarGoogle Scholar |
[52] Q Yao, R Chen, V Ganapathy, L Kou, Therapeutic application and construction of bilirubin incorporated nanoparticles. J Control Release 2020, 328, 407.
| Therapeutic application and construction of bilirubin incorporated nanoparticles.Crossref | GoogleScholarGoogle Scholar |
[53] O Afzal, MH Akhter, I Ahmad, K Muzammil, A Dawria, M Zeyaullah, et al. A β-sitosterol encapsulated biocompatible alginate/chitosan polymer nanocomposite for the treatment of breast cancer. Pharmaceutics. 2022, 14, 1711.
| A β-sitosterol encapsulated biocompatible alginate/chitosan polymer nanocomposite for the treatment of breast cancer.Crossref | GoogleScholarGoogle Scholar |
[54] (a) X Zhu, X Lei, J Wang, W Dong, Protective effects of resveratrol on hyperoxia-induced lung injury in neonatal rats by alleviating apoptosis and ROS production. J Matern Fetal Neonatal Med 2020, 33, 4150.
| Protective effects of resveratrol on hyperoxia-induced lung injury in neonatal rats by alleviating apoptosis and ROS production.Crossref | GoogleScholarGoogle Scholar |
(b) B Yan, L Cheng, Z Jiang, K Chen, C Zhou, L Sun, et al. Resveratrol inhibits ROS-promoted activation and glycolysis of pancreatic stellate cells via suppression of miR-21. Oxid Med Cell Longev 2018, 2018, 1346958.
| Resveratrol inhibits ROS-promoted activation and glycolysis of pancreatic stellate cells via suppression of miR-21.Crossref | GoogleScholarGoogle Scholar |
[55] Q Shi, X Wang, X Tang, N Zhen, Y Wang, Z Luo, et al. In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol. Food Sci Nutr 2021, 9, 3530.
| In vitro antioxidant and antitumor study of zein/SHA nanoparticles loaded with resveratrol.Crossref | GoogleScholarGoogle Scholar |
[56] T Wu, Y Liu, Y Cao, Z Liu, Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma. Adv Mater 2022, 34, e2110364.
| Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma.Crossref | GoogleScholarGoogle Scholar |
[57] B Ding, P Zheng, P Ma, J Lin, Manganese oxide nanomaterials: Synthesis, properties, and theranostic applications. Adv Mater 2020, 32, e1905823.
| Manganese oxide nanomaterials: Synthesis, properties, and theranostic applications.Crossref | GoogleScholarGoogle Scholar |
[58] R Zhang, X Song, C Liang, X Yi, G Song, Y Chao, et al. Catalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancer. Biomaterials. 2017, 138, 13.
| Catalase-loaded cisplatin-prodrug-constructed liposomes to overcome tumor hypoxia for enhanced chemo-radiotherapy of cancer.Crossref | GoogleScholarGoogle Scholar |
[59] Z Zeng, X He, C Li, S Lin, H Chen, L Liu, et al. Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease. Biomaterials. 2021, 271, 120753.
| Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease.Crossref | GoogleScholarGoogle Scholar |
[60] (a) A Jiso, P Demuth, M Bachowsky, M Haas, N Seiwert, D Heylmann, et al. Natural merosesquiterpenes activate the DNA damage response via DNA strand break formation and trigger apoptotic cell death in p53-wild-type and mutant colorectal cancer. Cancers (Basel) 2021, 13, 3282.
| Natural merosesquiterpenes activate the DNA damage response via DNA strand break formation and trigger apoptotic cell death in p53-wild-type and mutant colorectal cancer.Crossref | GoogleScholarGoogle Scholar |
(b) W Lim, S Park, FW Bazer, G Song, Naringenin-induced apoptotic cell death in prostate cancer cells is mediated via the PI3K/AKT and MAPK signaling pathways. J Cell Biochem 2017, 118, 1118.
| Naringenin-induced apoptotic cell death in prostate cancer cells is mediated via the PI3K/AKT and MAPK signaling pathways.Crossref | GoogleScholarGoogle Scholar |
(c) Q Xie, Y Chen, H Tan, B Liu, L-L Zheng, Y Mu, Targeting autophagy with natural compounds in cancer: A renewed perspective from molecular mechanisms to targeted therapy. Front Pharmacol 2021, 12, 748149.
| Targeting autophagy with natural compounds in cancer: A renewed perspective from molecular mechanisms to targeted therapy.Crossref | GoogleScholarGoogle Scholar |
[61] M Horie, Y Tabei, Role of oxidative stress in nanoparticles toxicity. Free Radic Res 2021, 55, 331.
| Role of oxidative stress in nanoparticles toxicity.Crossref | GoogleScholarGoogle Scholar |
[62] H Ming, B Li, H Tian, L Zhou, J Jiang, T Zhang, et al. A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer. Mater Today Bio 2022, 15, 100289.
| A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer.Crossref | GoogleScholarGoogle Scholar |
[63] S Lu, H Tian, L Li, B Li, M Yang, L Zhou, et al. Nanoengineering a zeolitic imidazolate framework-8 capable of manipulating energy metabolism against cancer chemo-phototherapy resistance. Small. 2022, 18, e2204926.
| Nanoengineering a zeolitic imidazolate framework-8 capable of manipulating energy metabolism against cancer chemo-phototherapy resistance.Crossref | GoogleScholarGoogle Scholar |
[64] W Jia, H Tian, J Jiang, L Zhou, L Li, M Luo, et al. Brain-targeted HFn-Cu-REGO nanoplatform for site-specific delivery and manipulation of autophagy and cuproptosis in glioblastoma. Small. 2023, 19, e2205354.
| Brain-targeted HFn-Cu-REGO nanoplatform for site-specific delivery and manipulation of autophagy and cuproptosis in glioblastoma.Crossref | GoogleScholarGoogle Scholar |
[65] L-S Lin, J-F Wang, J Song, Y Liu, G Zhu, Y Dai, Z Shen, et al. Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy. Theranostics 2019, 9, 7200.
| Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[66] N El Yamani, AR Collins, E Rundén-Pran, LM Fjellsbø, S Shaposhnikov, S Zienolddiny, et al. In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: Towards reliable hazard assessment. Mutagenesis. 2017, 32, 117.
| In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: Towards reliable hazard assessment.Crossref | GoogleScholarGoogle Scholar |
[67] S Makumire, VSK Chakravadhanula, G Köllisch, E Redel, A Shonhai, Immunomodulatory activity of zinc peroxide (ZnO2) and titanium dioxide (TiO2) nanoparticles and their effects on DNA and protein integrity. Toxicol Lett 2014, 227, 56.
| Immunomodulatory activity of zinc peroxide (ZnO2) and titanium dioxide (TiO2) nanoparticles and their effects on DNA and protein integrity.Crossref | GoogleScholarGoogle Scholar |
[68] (a) M Karimi, P Sahandi Zangabad, S Baghaee-Ravari, M Ghazadeh, H Mirshekari, MR Hamblin, Smart nanostructures for cargo delivery: Uncaging and activating by light. J Am Chem Soc 2017, 139, 4584.
| Smart nanostructures for cargo delivery: Uncaging and activating by light.Crossref | GoogleScholarGoogle Scholar |
(b) L Zhang, D Wang, K Yang, D Sheng, B Tan, Z Wang, et al. Mitochondria-targeted artificial “nano-RBCs” for amplified synergistic cancer phototherapy by a single NIR irradiation. Adv Sci (Weinh) 2018, 5, 1800049.
| Mitochondria-targeted artificial “nano-RBCs” for amplified synergistic cancer phototherapy by a single NIR irradiation.Crossref | GoogleScholarGoogle Scholar |
(c) P Jin, J Jiang, L Zhou, Z Huang, EC Nice, C Huang, et al. Mitochondrial adaptation in cancer drug resistance: Prevalence, mechanisms, and management. J Hematol Oncol 2022, 15, 97.
| Mitochondrial adaptation in cancer drug resistance: Prevalence, mechanisms, and management.Crossref | GoogleScholarGoogle Scholar |
[69] N Yang, W Xiao, X Song, W Wang, X Dong, Recent advances in tumor microenvironment hydrogen peroxide-responsive materials for cancer photodynamic therapy. Nano-Micro Lett 2020, 12, 15.
| Recent advances in tumor microenvironment hydrogen peroxide-responsive materials for cancer photodynamic therapy.Crossref | GoogleScholarGoogle Scholar |
[70] A Machuca , E Garcia-Calvo , DS Anunciação , JL Luque-Garcia , Rhodium Nanoparticles as a Novel Photosensitizing Agent in Photodynamic Therapy against Cancer. Chemistry 2020, 26, 7685.
| Rhodium Nanoparticles as a Novel Photosensitizing Agent in Photodynamic Therapy against Cancer.Crossref | GoogleScholarGoogle Scholar |
[71] J Dai, J Song, Y Qiu, J Wei, Z Hong, L Li, et al. Gold nanoparticle-decorated g-C3N4 nanosheets for controlled generation of reactive oxygen species upon 670 nm laser illumination. ACS Appl Mater Interfaces 2019, 11, 10589.
| Gold nanoparticle-decorated g-C3N4 nanosheets for controlled generation of reactive oxygen species upon 670 nm laser illumination.Crossref | GoogleScholarGoogle Scholar |
[72] AR Rastinehad, H Anastos, E Wajswol, JS Winoker, JP Sfakianos, SK Doppalapudi, et al. Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study. Proc Natl Acad Sci U S A 2019, 116, 18590.
| Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study.Crossref | GoogleScholarGoogle Scholar |
[73] R Baskaran, J Lee, S-G Yang, Clinical development of photodynamic agents and therapeutic applications. Biomater Res 2018, 22, 25.
| Clinical development of photodynamic agents and therapeutic applications.Crossref | GoogleScholarGoogle Scholar |
[74] Y Pan, Y Zhu, C Xu, C Pan, Y Shi, J Zou, et al. Biomimetic yolk-shell nanocatalysts for activatable dual-modal-image-guided triple-augmented chemodynamic therapy of cancer. ACS Nano 2022, 16, 19038.
| Biomimetic yolk-shell nanocatalysts for activatable dual-modal-image-guided triple-augmented chemodynamic therapy of cancer.Crossref | GoogleScholarGoogle Scholar |
[75] (a) W Zhang, C Liu, Z Liu, C Zhao, J Zhu, J Ren, et al. A cell selective fluoride-activated MOF biomimetic platform for prodrug synthesis and enhanced synergistic cancer therapy. ACS Nano 2022, 16, 20975.
| A cell selective fluoride-activated MOF biomimetic platform for prodrug synthesis and enhanced synergistic cancer therapy.Crossref | GoogleScholarGoogle Scholar |
(b) X Li, Q Zhou, AA-WMM Japir, D Dutta, N Lu, Z Ge, Protein-delivering nanocomplexes with fenton reaction-triggered cargo release to boost cancer immunotherapy. ACS Nano 2022, 16, 14982.
| Protein-delivering nanocomplexes with fenton reaction-triggered cargo release to boost cancer immunotherapy.Crossref | GoogleScholarGoogle Scholar |
[76] L Zhang, C-X Li, S-S Wan, X-Z Zhang, Nanocatalyst-mediated chemodynamic tumor therapy. Adv Healthc Mater 2022, 11, e2101971.
| Nanocatalyst-mediated chemodynamic tumor therapy.Crossref | GoogleScholarGoogle Scholar |
[77] (a) K Lin, Z Lin, Y Li, Y Zheng, D Zhang, Ultrasound-induced reactive oxygen species generation and mitochondria-specific damage by sonodynamic agent/metal ion-doped mesoporous silica. RSC Adv 2019, 9, 39924.
| Ultrasound-induced reactive oxygen species generation and mitochondria-specific damage by sonodynamic agent/metal ion-doped mesoporous silica.Crossref | GoogleScholarGoogle Scholar |
(b) X Guo, N Yang, W Ji, H Zhang, X Dong, Z Zhou, et al. Mito-bomb: Targeting mitochondria for cancer therapy. Adv Mater 2021, 33, e2007778.
| Mito-bomb: Targeting mitochondria for cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[78] J Huang, Z Xiao, Y An, S Han, W Wu, Y Wang, et al. Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy. Biomaterials. 2021, 269, 120636.
| Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[79] (a) A Shakeri, AFG Cicero, Y Panahi, M Mohajeri, A Sahebkar, Curcumin: A naturally occurring autophagy modulator. J Cell Physiol 2019, 234, 5643.
| Curcumin: A naturally occurring autophagy modulator.Crossref | GoogleScholarGoogle Scholar |
(b) E Tavana, H Mollazadeh, E Mohtashami, SMS Modaresi, A Hosseini, H Sabri, et al. Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme. Biofactors 2020, 46, 356.
| Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme.Crossref | GoogleScholarGoogle Scholar |
[80] M Kundu, P Sadhukhan, N Ghosh, S Chatterjee, P Manna, J Das, et al. pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy. J Adv Res 2019, 18, 161.
| pH-responsive and targeted delivery of curcumin via phenylboronic acid-functionalized ZnO nanoparticles for breast cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[81] P Sadhukhan, M Kundu, S Chatterjee, N Ghosh, P Manna, J Das, et al. Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy. Mater Sci Eng C Mater Biol Appl 2019, 100, 129.
| Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy.Crossref | GoogleScholarGoogle Scholar |
[82] N Yang, R-R Zheng, Z-Y Chen, R-X Wang, L-P Zhao, X-Y Chen, et al. A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption. Biomater Sci 2022, 10, 1575.
| A carrier free photodynamic oxidizer for enhanced tumor therapy by redox homeostasis disruption.Crossref | GoogleScholarGoogle Scholar |
[83] (a) B Li, J Jiang, YG Assaraf, H Xiao, Z-S Chen, C Huang, Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification. Drug Resist Updat 2020, 53, 100720.
| Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification.Crossref | GoogleScholarGoogle Scholar |
(b) P Jin, J Jiang, L Zhou, Z Huang, S Qin, H-N Chen, et al. Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis. EMBO Mol Med 2022, 14, e16082.
| Disrupting metformin adaptation of liver cancer cells by targeting the TOMM34/ATP5B axis.Crossref | GoogleScholarGoogle Scholar |
[84] J Shi, PW Kantoff, R Wooster, OC Farokhzad, Cancer nanomedicine: Progress, challenges and opportunities. Nat Rev Cancer 2017, 17, 20.
| Cancer nanomedicine: Progress, challenges and opportunities.Crossref | GoogleScholarGoogle Scholar |
[85] L-S Lin, J-F Wang, J Song, Y Liu, G Zhu, Y Dai, et al. Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy. Theranostics. 2019, 9, 7200.
| Cooperation of endogenous and exogenous reactive oxygen species induced by zinc peroxide nanoparticles to enhance oxidative stress-based cancer therapy.Crossref | GoogleScholarGoogle Scholar |
