A Scalable, Combined-Batch, and Continuous-Flow Synthesis of a Bio-Inspired UV-B Absorber
Mark York A C , Karen E. Jarvis A , Jamie A. Freemont A , John H. Ryan A , G. Paul Savage A , Stephanie A. Logan A and Larissa Bright B
+ Author Affiliations
- Author Affiliations
A CSIRO Manufacturing, CSIRO, Clayton, Vic. 3168, Australia.
B Coral Sunscreen Pty Ltd, Aitkenvale, Qld 4814, Australia.
C Corresponding author. Email: mark.york@csiro.au
Australian Journal of Chemistry 72(11) 860-866 https://doi.org/10.1071/CH19252
Submitted: 3 June 2019 Accepted: 5 July 2019 Published: 24 July 2019
Abstract
A new, chromatography-free synthesis for the preparation of an experimental UV-B absorber is reported. A key step of the process is a one-pot partial reduction of a symmetrical imide with a sequential dehydration step. The synthesis uses several continuous-flow steps to increase sample throughput and was used to prepare sufficient material to support further testing activities in >99 % purity.
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