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RESEARCH ARTICLE
Contents Vol 72(5)

Microwave-Assisted Synthesis, Characterisation, and DNA-Binding Properties of RuII Complexes Coordinated by Norfloxacin as Potential Tumour Inhibitors

Xukui Liu A , Xuanhao Zhao A , Yumei Li A , Kangdi Zheng A , Qiong Wu A D and Wenjie Mei A B C D
+ Author Affiliations
- Author Affiliations

A School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.

B Guangdong Province Engineering Technology Centre for Molecular Probes and Biomedicine Imaging, Guangzhou 510006, China.

C Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems, Guangdong Pharmaceutical University, Guangzhou 510006, China.

D Corresponding authors. Email: wuqiongniu.1113@163.com; wenjiemei@126.com

Australian Journal of Chemistry 72(5) 400-406 https://doi.org/10.1071/CH18637
Submitted: 7 January 2019  Accepted: 7 February 2019   Published: 1 March 2019

Abstract

Three novel norfloxacin-based ruthenium(ii) complexes, [Ru(bpy)2(NFLX)]Cl·2H2O (1), [Ru(phen)2(NFLX)]Cl·2H2O (2), and [Ru(dmbpy)2(NFLX)]Cl·2H2O (3) (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dmbpy = 4,4′-dimethyl-2,2′-bipyridine, and NFLX = norfloxacin), were synthesised and characterised with electrospray ionisation mass spectrometry and 1H and 13C NMR spectroscopy. The antitumour properties were evaluated by MTT assay, and the data revealed that 2 can inhibit the growth of human lung adenocarcinoma A549 efficiently. Furthermore, the DNA-binding behaviours of these complexes were investigated by a multiple spectroscopy assay and viscosity study. The results indicated that these complexes interact with calf thymus DNA through electrostatic interactions with a strong binding affinity in the order 2 > 3 > 1. Therefore, these results suggested that 2 might be a suitable anticancer agent due to its excellent DNA-binding abilities.


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