Microfluidic Radiosynthesis of the Muscarinic M2 Imaging Agent [18F]FP-TZTP*

Lidia Matesic; Ivan Greguric; Giancarlo Pascali

doi:10.1071/CH18266

RESEARCH ARTICLE

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Microfluidic Radiosynthesis of the Muscarinic M₂ Imaging Agent [¹⁸F]FP-TZTP*

Lidia Matesic ^A ^D , Ivan Greguric ^A ^B and Giancarlo Pascali ^A ^C

+ Author Affiliations

- Author Affiliations

^A Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC, NSW 2232, Australia.

^B Australian Centre of Nanomedicine, School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.

^C Brain and Mind Centre, The University of Sydney, Mallett Street, Camperdown, NSW 2050, Australia.

^D Corresponding author. Email: lidia.matesic@ansto.gov.au

Australian Journal of Chemistry 71(10) 811-817 https://doi.org/10.1071/CH18266
Submitted: 1 June 2018 Accepted: 1 August 2018 Published: 31 August 2018

Abstract

3-(4-(3-[¹⁸F]Fluoropropylthio)-1,2,5-thiadiazol-3-yl)-1-methyl-1,2,5,6-tetrahydropyridine ([¹⁸F]FP-TZTP) is a selective ¹⁸F-radiotracer for the muscarinic acetylcholine receptor subtype M₂, which can be used to perform positron emission tomography (PET) scans on patients with neurological disorders such as Alzheimer’s disease. [¹⁸F]FP-TZTP was produced using continuous-flow microfluidics, a technique that uses reduced amounts of chemical reagents, shorter reaction times and in general, results in higher radiochemical yields compared to currently used techniques. The optimal ¹⁸F-radiolabelling conditions consisted of a total flow rate of 40 µL min⁻¹ and 190°C, which produced [¹⁸F]FP-TZTP in 26 ± 10 % radiochemical yield with a molar activity of 182 ± 65 GBq µmol⁻¹ and >99 % radiochemical purity.

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