Water-Soluble Poly(ϵ-caprolactone)-Paclitaxel Prodrugs Toward an Efficient Drug Delivery System
Ji Wang A , Huanjiao Sun A , Deshan Li A , Jie Yuan A , Xuefei Zhang A B C and Haoyu Tang A B C
+ Author Affiliations
- Author Affiliations
A College of Chemistry, Xiangtan University, Xiangtan 411105, Hunan Province, China.
B Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, Key Laboratory of Polymeric Materials and Application Technology of Hunan Province, and Universities of Hunan Province, Xiangtan 411105, China.
C Corresponding authors. Email: zxf7515@163.com; htang@xtu.edu.cn
Australian Journal of Chemistry 68(7) 1136-1143 https://doi.org/10.1071/CH14517
Submitted: 23 August 2014 Accepted: 8 December 2014 Published: 18 February 2015
Abstract
In this paper, poly(ϵ-caprolactone)-graft-carboxylic acid (P(α-C2CL)) was prepared via a thio-bromo click reaction between mercaptosuccinic acid and poly(α-bromo-ϵ-caprolactone). It is readily soluble in aqueous solutions (pH 5.5–9.8) due to the presence of carboxylic groups in each repeating unit. A series of water-soluble P(α-C2CL)-paclitaxel prodrugs with high drug contents (up to 41.4 wt-%) was prepared by esterification. Meanwhile, methyl tetrazolium (MTT) assays showed that P(α-C2CL)-paclitaxel prodrugs exhibited a high antitumour effect on A549 and MCF-7 cells. These prodrugs have appeared as a highly versatile and potent platform for cancer therapy.
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