[18F]Fluorination Optimisation and the Fully Automated Production of [18F]MEL050 Using a Microfluidic System
Lidia Matesic A D , Annukka Kallinen A B , Naomi A. Wyatt A , Tien Q. Pham A , Ivan Greguric A C and Giancarlo Pascali AA LifeSciences Division, Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC, NSW 2232, Australia.
B Laboratory of Radiochemistry, Department of Chemistry, University of Helsinki, PO Box 55, Helsinki, 00014, Finland.
C Australian Centre for Nanomedicine, School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia.
D Corresponding author. Email: lidia.matesic@ansto.gov.au
Australian Journal of Chemistry 68(1) 69-71 https://doi.org/10.1071/CH14130
Submitted: 10 March 2014 Accepted: 30 April 2014 Published: 6 June 2014
Abstract
The [18F]radiolabelling of the melanin-targeting positron-emission tomography radiotracer [18F]MEL050 was rapidly optimised using a commercial continuous-flow microfluidic system. The optimal [18F]fluorination incorporation conditions were then translated to production-scale experiments (35–150 GBq) suitable for preclinical imaging, complete with automated HPLC–solid phase extraction purification and formulation. [18F]MEL050 was obtained in 43 ± 10 % radiochemical yield in ~50 min.
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