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RESEARCH FRONT
Contents Vol 66(12)

Fragment-based Drug Discovery: the Shape of Things to Come

Martin J. Drysdale
+ Author Affiliations
- Author Affiliations

Drug Discovery Programme, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK. Email: m.drysdale@beatson.gla.ac.uk

Australian Journal of Chemistry 66(12) 1544-1549 https://doi.org/10.1071/CH13255
Submitted: 15 May 2013  Accepted: 28 June 2013   Published: 5 August 2013

Abstract

Fragment-Based Drug Discovery (FBDD) is here to stay. Validated as a technology with the delivery of Zelboraf (Vemurafenib) for the treatment of mutant B-RafV600E melanoma, it has become embedded within the pharmaceutical and biotechnology industries. FBDD has delivered clinical development candidates for a broad range of targets including some of the most challenging cases such as β-secretase (BACE1) and protein–protein interactions. But the best is surely still to come.


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