Degradable Dextran Particles for Gene Delivery Applications
Peter R. Wich A and Jean M. J. Fréchet A B
+ Author Affiliations
- Author Affiliations
A College of Chemistry, University of California, Berkeley, California 94720-1460, USA.
B Corresponding author. Email: frechet@berkeley.edu
Australian Journal of Chemistry 65(1) 15-19 https://doi.org/10.1071/CH11370
Submitted: 17 September 2011 Accepted: 16 October 2011 Published: 29 November 2011
Abstract
Successful gene therapy depends both on the effective transport and the stable expression of therapeutic genes to produce and regulate disease related proteins. In this context, non-viral gene delivery vehicles are regarded as one of the most promising approaches for the efficient and safe transport of genetic material to and into the target cells. This short review describes the development of novel particulate delivery vehicles based on the biopolymer dextran. This multifunctional platform was designed to safely transport genetic material across cell membranes, followed by an acid triggered release that causes overall high transfection efficiency. The biocompatibility and its unique tunability differentiate this new carrier system from previous particle systems, showing high potential for the treatment of several disease models in RNA interference related applications.
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