Synthesis, Structural, and Insulin-Enhancing Studies of Oxovanadium(iv) Complexes
Adeola A. Nejo A C D , Gabriel A. Kolawole A , Ayorinde O. Nejo A , Tebogo V. Segapelo A and Christo J. Muller BA Department of Chemistry, University of Zululand, Private Bag X1001, Kwadlangezwa 3886, South Africa.
B Diabetic Discovery Platform, South African Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa.
C Department of Chemical and Environmental Sciences, Babcock University, Ilisan-Remo, Ogun State, P.M.B. 21244, Ikeja, Lagos, Nigeria.
D Corresponding author. Email: anejo@pan.uzulu.ac.za
Australian Journal of Chemistry 64(12) 1574-1579 https://doi.org/10.1071/CH11291
Submitted: 14 July 2011 Accepted: 19 September 2011 Published: 17 October 2011
Abstract
Oxovanadium(iv) complexes with Schiff bases derived from substituted salicylaldehyde and diamine have been prepared and characterized. 1H NMR and IR spectral data revealed that the symmetrical Schiff base was isolated, and elemental analysis confirmed the purity of all the compounds as formulated. The room-temperature magnetic moments of 1.6–1.8 Bohr magneton for the complexes confirmed that the complexes are VIV complexes, with d1 configuration. Cyclic voltammetry revealed only one quasi-reversible wave for each complex and they all showed redox couples with peak-to-peak separation values (ΔEp) ranging from 76 to 84 mV, indicating a single-step one-electron transfer process. An oral administration of these complexes supplied at a dose of 0.2 mmol kg–1 to streptozotocin-induced diabetic rats elicited a progressive reduction in plasma glucose over 6-h periods. Two of the complexes produced significant and consistent reduction in fasting blood glucose levels over a 6-h monitoring period.
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