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RESEARCH FRONT
Contents Vol 64(6)

Mass Spectrometry for Structural Biology: Determining the Composition and Architecture of Protein Complexes

Tara L. Pukala A
+ Author Affiliations
- Author Affiliations

A School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia. Email: tara.pukala@adelaide.edu.au




Dr. Tara Pukala obtained a Ph.D. from the University of Adelaide (with Professor J. H. Bowie) which was followed by a postdoctoral role at the University of Cambridge, UK (with Professor C. V. Robinson). She returned to a lectureship position at the University of Adelaide in 2008, where she has established a research group focussed on the development and application of mass spectrometric and related technologies for the investigation of biomolecular systems.

Australian Journal of Chemistry 64(6) 681-691 https://doi.org/10.1071/CH11025
Submitted: 14 January 2011  Accepted: 8 March 2011   Published: 27 June 2011

Abstract

Knowledge of protein structure and protein–protein interactions is vital for appreciating the elaborate biochemical pathways that underlie cellular function. While many techniques exist to probe the structure and complex interplay between functional proteins, none currently offer a complete picture. Mass spectrometry and associated methods provide complementary information to established structural biology tools, and with rapidly evolving technological advances, can in some cases even exceed other techniques by its diversity in application and information content. This is primarily because of the ability of mass spectrometry to precisely identify protein complex stoichiometry, detect individual species present in a mixture, and concomitantly offer conformational information. This review describes the attributes of mass spectrometry for the structural investigation of multiprotein assemblies in the context of recent developments and highlights in the field.


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