Water-soluble Bis(thiosemicarbazonato)copper(ii) Complexes
Gojko Buncic A , James L. Hickey A , Christine Schieber A , Jonathan M. White A , Peter J. Crouch B , Anthony R. White B , Zhiguang Xiao A , Anthony G. Wedd A and Paul S. Donnelly A C
+ Author Affiliations
- Author Affiliations
A School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Melbourne, Vic. 3010, Australia.
B Centre for Neuroscience and Department of Pathology, University of Melbourne, Parkville, Melbourne, Vic. 3010, Australia.
C Corresponding author. Email: pauld@unimelb.edu.au
Australian Journal of Chemistry 64(3) 244-252 https://doi.org/10.1071/CH10463
Submitted: 17 December 2010 Accepted: 17 January 2011 Published: 11 March 2011
Abstract
The synthesis of four new water-soluble bis(thiosemicarbazone) ligands and their copper(ii) complexes is presented and their potential to be new ligands for copper radiopharmaceuticals is discussed. The ligands and complexes have been characterized by a combination of NMR spectroscopy, mass spectrometry, and X-ray crystallography. The electrochemical behaviour of two of the copper(ii) complexes was investigated by cyclic voltammetry and revealed that both complexes exhibited a quasi-reversible redox process attributed to a CuII/CuI process. Two of the new ligands were radiolabelled with positron-emitting 64Cu with a view to assessing their potential as ligands that bind radioactive copper isotopes for application in diagnostic radiopharmaceuticals. The cellular uptake of the copper complexes was investigated in SH-SY5Y cells.
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