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RESEARCH ARTICLE
Contents Vol 64(3)

Crystal Structures, Antioxidation, and DNA Binding Properties of SmIII Complexes

Yongchun Liu A B , Zhengyin Yang A C , Kejun Zhang B , Yun Wu B , Jihua Zhu B and Tianlin Zhou B
+ Author Affiliations
- Author Affiliations

A College of Chemistry and Chemical Engineering, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, 730000 Lanzhou, China.

B College of Chemistry and Chemical Engineering, Key Laboratory of Longdong Biological Resources in Gansu Province, Longdong University, 745000 Qingyang, Gansu, China.

C Corresponding author. Email: yangzy@lzu.edu.cn

Australian Journal of Chemistry 64(3) 345-354 https://doi.org/10.1071/CH10302
Submitted: 12 August 2010  Accepted: 7 February 2011   Published: 11 March 2011

Abstract

The dinuclear SmIII complexes with 1:1 metal to ligand stoichiometry were prepared from Sm(NO3)3·6H2O and three anionic tetradentate Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxyaldehyde with benzoylhydrazine, 2-hydroxybenzoylhydrazine, and isonicotinylhydrazine, respectively. All the ligands and complexes can bind strongly to calf thymus DNA through intercalation with the binding constants at 105–106 M–1, but complexes present stronger affinities to DNA than ligands. All the ligands and complexes have strong abilities of antioxidation, but complexes and ligands containing an active phenolic hydroxy group show stronger scavenging effects on hydroxyl radical, and SmIII complex containing N-heteroaromatic substituent shows stronger scavenging effects for superoxide radical.


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