Rapid, Chemoenzymatic Syntheses of the Epoxyquinols (–)-Bromoxone Acetate and (–)-Tricholomenyn A

David M. Pinkerton; Martin G. Banwell; Anthony C. Willis

doi:10.1071/CH09469

RESEARCH ARTICLE

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Rapid, Chemoenzymatic Syntheses of the Epoxyquinols (–)-Bromoxone Acetate and (–)-Tricholomenyn A

David M. Pinkerton ^A , Martin G. Banwell ^A ^B and Anthony C. Willis ^A

+ Author Affiliations

- Author Affiliations

^A Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia.

^B Corresponding author. Email: mgb@rsc.anu.edu.au

Australian Journal of Chemistry 62(12) 1639-1645 https://doi.org/10.1071/CH09469
Submitted: 7 September 2009 Accepted: 20 October 2009 Published: 10 December 2009

Abstract

The epoxyquinol derivatives (–)-bromoxone acetate (ent-1) and (–)-tricholomenyn A (2) have been prepared from the cis-1,2-dihydrocatechols 3 and 4, respectively. Compounds 3 and 4 are themselves obtained in enantiomerically pure form through the whole-cell biotransformation of the corresponding halobenzene.

Acknowledgements

We thank the Institute of Advanced Studies and the Australian Research Council for financial support.

References

Rapid, Chemoenzymatic Syntheses of the Epoxyquinols (–)-Bromoxone Acetate and (–)-Tricholomenyn A

Abstract

Acknowledgements

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