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Synthesis and Applications of Covalent Protein-DNA Conjugates

Patrick M. Schaeffer ^A ^C and Nicholas E. Dixon ^B

+ Author Affiliations

- Author Affiliations

^A Comparative Genomics Center, School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Qld 4811, Australia.

^B School of Chemistry, University of Wollongong, NSW 2522, Australia.

^C Corresponding author. Email: patrick.schaeffer@jcu.edu.au

Australian Journal of Chemistry 62(10) 1328-1332 https://doi.org/10.1071/CH09164
Submitted: 18 March 2009 Accepted: 4 May 2009 Published: 13 October 2009

Abstract

Synthetic protein-DNA conjugates are valuable tools with applications in fields including nanobiotechnology, bioanalytical chemistry, and molecular diagnostics, and various synthetic methods for their production have been developed during the past three decades. The present article reviews current methodologies for the synthesis of covalent protein-DNA conjugates with particular focus on the regiospecificity and stoichiometry of these reactions.

Acknowledgement

Our work in this area is supported by a project grant from the NHMRC, Australia.

References

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