Water-Mediated Synthesis of 2-Substituted Benzimidazoles by Boric Acid and Glycerol

Chhanda Mukhopadhyay; Pradip Kumar Tapaswi; Ray J. Butcher

doi:10.1071/CH08309

RESEARCH ARTICLE

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Water-Mediated Synthesis of 2-Substituted Benzimidazoles by Boric Acid and Glycerol

Chhanda Mukhopadhyay ^A ^C , Pradip Kumar Tapaswi ^A and Ray J. Butcher ^B

+ Author Affiliations

- Author Affiliations

^A Department of Chemistry, University of Calcutta, 92, APC Road, Kolkata-700009, India.

^B Department of Chemistry, Howard University, Washington, DC 20059, USA.

^C Corresponding author. Email: csm@vsnl.net; cmukhop@yahoo.co.in

Australian Journal of Chemistry 62(2) 140-144 https://doi.org/10.1071/CH08309
Submitted: 19 July 2008 Accepted: 29 November 2008 Published: 19 February 2009

Abstract

A very simple, mild, and highly efficient green catalyst has been developed for the synthesis of 2-substituted benzimidazoles by treatment of substituted ortho-phenylenediamines and aldehydes in water at 80°C in the presence of boric acid (5 mol-%) and glycerol (0.05 mL). This methodology has been standardized on 55 substrates, and nine new compounds have been synthesized.

Acknowledgement

The authors thank the CAS Instrumentation Facility, University of Calcutta, for spectroscopic data. P.K.T. thanks UGC (New Delhi) for his fellowship (JRF).

References

Water-Mediated Synthesis of 2-Substituted Benzimidazoles by Boric Acid and Glycerol

Abstract

Acknowledgement

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