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RESEARCH FRONT
Contents Vol 61(9)

Physiological Targeting to Improve Anticancer Drug Selectivity

Trevor W. Hambley A
+ Author Affiliations
- Author Affiliations

A School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia. Email: t.hambley@chem.usyd.edu.au

Australian Journal of Chemistry 61(9) 647-653 https://doi.org/10.1071/CH08180
Submitted: 29 April 2008  Accepted: 22 July 2008   Published: 5 September 2008

Abstract

The physiological differences between solid tumours and the healthy tissues and organs of the body are both an impediment to effective treatment and a potential basis for targeting strategies. In the present review, we outline the physiological features that distinguish tumours including hypoxia, acidity, and inhibited transport and describe the strategies being employed to exploit these differences in order to generate more selective and less toxic anticancer agents.


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