Microwave Induced Synthesis of O,O-Dialkyl Dialkylpyrophosphonates under Solvent Free Conditions: Markers of Nerve Agents

Rajesh Kumar; Deepak Pardasani; Avik Mazumder; Devendra K. Dubey; Arvind K. Gupta

doi:10.1071/CH07375

RESEARCH ARTICLE

Previous Contents Vol 61(6)

Microwave Induced Synthesis of O,O-Dialkyl Dialkylpyrophosphonates under Solvent Free Conditions: Markers of Nerve Agents

Rajesh Kumar ^A , Deepak Pardasani ^A , Avik Mazumder ^A , Devendra K. Dubey ^A and Arvind K. Gupta ^A ^B

+ Author Affiliations

- Author Affiliations

^A Vertox Laboratory Defence R & D Establishment, Jhansi Road, Gwalior-474002 (MP), India.

^B Corresponding author. Email: arvindkumargupta2@rediffmail.com

Australian Journal of Chemistry 61(6) 476-480 https://doi.org/10.1071/CH07375
Submitted: 25 October 2007 Accepted: 16 April 2008 Published: 19 June 2008

Abstract

This article describes a one pot, solvent free, microwave assisted synthesis of O,O-dialkyl dialkylpyrophosphonates (DADAPP) from O-alkyl alkylphosphonic chlorides 2a–j with 4-dimethylaminopyridine (DMAP) in the presence of water under microwave irradiation. The reaction takes place by the phosphonium salts, which are converted into the DADAPPs 4a–j. These DADAPPs are important markers of chemical warfare agents sarin, soman, and VX and their analogues. The method has several advantages over the conventional methods such as operational simplicity, high yield, and reduced reaction time.

Acknowledgements

The authors thank Ms. Mamta Sharma for NMR analysis.

References

Microwave Induced Synthesis of O,O-Dialkyl Dialkylpyrophosphonates under Solvent Free Conditions: Markers of Nerve Agents

Abstract

Acknowledgements

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