Copper(ii) Complexes with Reduced Schiff Base: Synthesis, Spectroscopic, Thermal, X-Ray, and Cytotoxic Studies of Novel Copper(ii) Complexes with an Arylpyrazole Ligand

Vukadin M. Leovac; Petra Bombicz; Katalin Mészáros Szécsényi; Milan D. Joksović

doi:10.1071/CH07183

RESEARCH ARTICLE

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Copper(ii) Complexes with Reduced Schiff Base: Synthesis, Spectroscopic, Thermal, X-Ray, and Cytotoxic Studies of Novel Copper(ii) Complexes with an Arylpyrazole Ligand

Vukadin M. Leovac ^A , Petra Bombicz ^B , Katalin Mészáros Szécsényi ^A and Milan D. Joksović ^D ^D

+ Author Affiliations

- Author Affiliations

^A Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia.

^B Institute of Structural Chemistry, Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H-1525 Budapest, Hungary.

^C Faculty of Sciences, University of Kragujevac, R. Domanovica 12, 34000 Kragujevac, Serbia.

^D Corresponding author. Email: mjoksovic@kg.ac.yu

Australian Journal of Chemistry 60(8) 615-620 https://doi.org/10.1071/CH07183
Submitted: 30 May 2007 Accepted: 6 July 2007 Published: 9 August 2007

Abstract

The synthesis of a novel arylpyrazole-derived ligand, 1,2-bis[(1,3-diphenylpyrazol-4-yl)methyl]diaminoethane (Ph₄Pz₂mde), and its complexes prepared with CuCl₂ [Cu(Ph₄Pz₂mde)Cl₂(MeOH)] 1, CuBr₂ [Cu(Ph₄Pz₂mde)Br₂(MeOH)] 2, from MeOH, and [Cu(Ph₄Pz₂mde)Cl₂(DMF)] 3, from a mixture of MeOH and DMF, are described. The complexes are characterized by elemental and thermal analysis and FT-IR spectroscopy, while the ¹H and ¹³C NMR assignments are given for the ligand. The crystal and molecular structure of [Cu(Ph₄Pz₂mde)Cl₂(DMF)] was determined by single-crystal X-ray diffraction. In-vitro cytotoxicity of the Ph₄Pz₂mde ligand and two copper(ii) complexes was obtained using sulforhodamine B (SRB) treatment against three human tumour cell lines: HeLa (epitheloid carcinoma of cervix), MCF-7 (breast adenocarcinoma), and MRC-5 (lung fetal fibroblasts).

Acknowledgments

A diffractometer purchase grant from the Hungarian National Office for Research and Technology (MU-00338/2003) is gratefully acknowledged. This work was financed by the Ministry for Science and Environmental Protection of the Republic of Serbia (grant no. 142028) and the Provincial Secretariat for Science and Technological Development of Vojvodina. We also thank Ms Gordana Bogdanović and Ms Vesna Kojić, Institute of Oncology, Experimental Oncology Department, Sremska Kamenica, Serbia for biological evaluation of our synthesized compounds.

References

Copper(ii) Complexes with Reduced Schiff Base: Synthesis, Spectroscopic, Thermal, X-Ray, and Cytotoxic Studies of Novel Copper(ii) Complexes with an Arylpyrazole Ligand

Abstract

Acknowledgments

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