Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-Hydroxyethyl Methacrylate) Hydrogels

Traian V. Chirila; Anita J. Hill; David T. Richens

doi:10.1071/CH07111

RESEARCH ARTICLE

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Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-Hydroxyethyl Methacrylate) Hydrogels

Traian V. Chirila ^A ^B ^C ^G , Anita J. Hill ^D ^E and David T. Richens ^F

+ Author Affiliations

- Author Affiliations

^A Queensland Eye Institute, 41 Annerley Road, South Brisbane, QLD 4101, Australia.

^B School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, QLD 4001, Australia.

^C Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia.

^D CSIRO Manufacturing and Infrastructure Technology, Private Bag 33, Clayton, VIC 3168, Australia.

^E School of Chemistry, Monash University, Clayton, VIC 3800, Australia.

^F School of Chemistry, University of St Andrews, Fife, KY16 9ST, Scotland, UK.

^G Corresponding author. Email: traian.chirila@qei.org.au

Australian Journal of Chemistry 60(6) 439-443 https://doi.org/10.1071/CH07111
Submitted: 12 January 2007 Accepted: 2 May 2007 Published: 18 June 2007

Abstract

A method is described that allows reduction of the amount of calcium phosphate phases deposited spontaneously inside poly(2-hydroxyethyl methacrylate) (PHEMA), a hydrogel of biomedical importance. PHEMA homo-interpenetrating polymer networks (homo-IPNs) were synthesized and then treated in a calcifying solution. A reduction of calcium uptake of 58 to 75% was measured by ICP emission spectroscopy in the IPNs as compared to the PHEMA homopolymer (the parent network). The effect was rationalized in terms of reduction of the free volume available for the penetration and transport of Ca²⁺ and phosphate ions as a result of redundant chain packing through formation of IPNs.

Acknowledgments

This study was supported in part by the Australian Research Council (grant DP0208223) and by the Sylvia & Charles Viertel Charitable Foundation (Queensland).

References

Effect of Redundant Chain Packing on the Uptake of Calcium Phosphate in Poly(2-Hydroxyethyl Methacrylate) Hydrogels

Abstract

Acknowledgments

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