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RESEARCH ARTICLE

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A Facile and Efficient Synthesis of Functionalized γ-Butyrolactones from Baylis–Hillman Adducts of Isatin

Ponnusamy Shanmugam ^A ^B , Vadivel Vaithiyanathan ^A and Baby Viswambharan ^A

+ Author Affiliations

- Author Affiliations

^A Chemical Sciences and Technology Division, Regional Research Laboratory (CSIR), Thiruvananthapuram-695 019, Kerala, India.

^B Corresponding author. Email: shanmu196@rediffmail.com

Australian Journal of Chemistry 60(4) 296-301 https://doi.org/10.1071/CH07020
Submitted: 23 January 2007 Accepted: 6 March 2007 Published: 26 April 2007

Abstract

A facile and efficient stereoselective synthesis of functionalized substituted γ-butyrolactones in excellent yield from the Baylis–Hillman adducts of isatin derivatives by a reductive cyclization methodology is reported.

Acknowledgments

The authors thank Professor Dr T. K. Chandrashekar, Director, RRL-T, for providing infrastructure facilities. Financial support from the DST (New Delhi) vide sanction no. SR/S1/OC-38/2005 is acknowledged. V.V. and B.V. thank CSIR (New Delhi) for the award of a Senior Research Fellowship. Thanks are due to Mrs Viji for providing HRMS data.

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