Olefin Metathesis: Catalyst Development, Microwave Catalysis, and Domino Applications
Steven G. Aitken A and Andrew D. Abell A BA Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
B Corresponding author. Email: andrew.abell@canterbury.ac.nz
Steve Aitken is a graduate of the University of East Anglia, UK. He joined SmithKline Beecham, later GlaxoSmithKline, as a research chemist. During this period he completed a postgraduate certificate in Structure Based Drug Design at the University of Nottingham, UK. He briefly worked for Carlton and United Breweries, Australia, before returning to GlaxoSmithKline in psychiatric drug discovery. In late 2003 he emigrated to Christchurch, New Zealand, and is currently studying his Ph.D., on the application of ring closing metathesis to the synthesis of conformationally constrained peptidomimetics, at the University of Canterbury. |
Andrew Abell obtained a B.Sc.(Hons1) in Organic Chemistry from the University of Adelaide, and a Ph.D. from the same university, under the supervision of Raph Massy-Westropp. He then spent two years working as a postdoctoral fellow with Alan Battersby at Cambridge University, UK, and in 1988 he took a position at the University of Canterbury, New Zealand. His current research interests include the design, synthesis, and biological properties of peptidomimetics and other molecules that mimic or inhibit important biologically active compounds and processes. |
Australian Journal of Chemistry 58(1) 3-13 https://doi.org/10.1071/CH04153
Submitted: 17 June 2004 Accepted: 14 October 2004 Published: 14 January 2005
Abstract
Olefin metathesis, a process by which alkylidene groups on alkenes are exchanged, is reviewed with reference to the historical development of functional catalysts and microwave catalysis. The advent of new catalysts and improved reaction conditions has paved the way for the development of new and versatile domino processes that combine either different metathesis events or a key metathesis reaction with another reaction in a particularly atom economic and ‘green’ sense. We review this area as a convenient route to some otherwise difficult to prepare systems.
Acknowledgments
A.D.A. thanks the many research students who have worked with him on the development of metathesis chemistry for the synthesis of new peptidomimetics over the last few years. The authors also thank the University of Canterbury for continuing support and acknowledge the funding received from the New Zealand Royal Society Marsden Fund.
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