Stereoselective Synthesis of the Hydrophobic Side Chain of Scyphostatin
Ryukichi Takagi, Shinjiro Tsuyumine, Hiroko Nishitani, Wataru Miyanaga and
Katsuo Ohkata
Australian Journal of Chemistry
57(5) 439 - 447
Published: 07 May 2004
Abstract
The hydrophobic side chain of scyphostatin was synthesized by a convergent synthetic pathway. The key reactions were the enzymatic asymmetric acetylation of a meso-diol, construction of the C12′–C13′ trisubstituted E-olefin moiety by Negishi coupling, and construction of the (2′E,4′E ,E,6′E)-triene moiety by Horner–Wadsworth–Emmons olefination.https://doi.org/10.1071/CH03298
© CSIRO 2004
