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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Stereoselective Synthesis of the Hydrophobic Side Chain of Scyphostatin

Ryukichi Takagi, Shinjiro Tsuyumine, Hiroko Nishitani, Wataru Miyanaga and Katsuo Ohkata

Australian Journal of Chemistry 57(5) 439 - 447
Published: 07 May 2004

Abstract

The hydrophobic side chain of scyphostatin was synthesized by a convergent synthetic pathway. The key reactions were the enzymatic asymmetric acetylation of a meso-diol, construction of the C12′–C13′ trisubstituted E-olefin moiety by Negishi coupling, and construction of the (2′E,4′E ,E,6′E)-triene moiety by Horner–Wadsworth–Emmons olefination.

https://doi.org/10.1071/CH03298

© CSIRO 2004

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