Synthesis of Nitrogen Heterocycles by Rhodium-Catalyzed Hydroformylation of Polymer-Attached Amino Alkenes with Syngas

Abstract

Rhodium(I) phosphite catalyzed hydroaminomethylation of resin-tethered amino alkenes with H₂/CO gives moderate to good yields of five-, eight-, ten-, and thirteen-membered heterocycles. Competing hydrogenation, dimerization, or polymerization reactions were not observed using this methodology.