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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Total Synthesis of (+)-Crocacin A

John T. Feutrill and Mark A. Rizzacasa

Australian Journal of Chemistry 56(8) 783 - 785
Published: 18 July 2003

Abstract

The first asymmetric total synthesis of the electron-transport inhibitor crocacin A (1) is described. The key step involved acylation of the anion derived from dienecarbamate (6) with the acid chloride (5) to afford the enamide (14). Desilylation, oxidation, and N-deprotection gave acid (17), which was coupled with glycine methyl ester to afford (1).

https://doi.org/10.1071/CH03026

© CSIRO 2003

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