Components for Tethered Bilayer Membranes: Synthesis of Hydrophilically Substituted Phytanol Derivatives
Christopher J. Burns, Leslie D. Field, Jacqueline Morgan, Brian J. Petteys, Jognandan Prashar,
Damon D. Ridley, K. R. A. Samankumara Sandanayake and Valentina Vignevich
Australian Journal of Chemistry
54(7) 431 - 438
Published: 19 December 2001
Abstract
In order to optimize the performance of the AMBRI™ biosensor (Nature 1997, 387, 580), a variety of hydrophilic linkers between the hydrophobic bilayer membrane and the gold surface have been synthesized. The principal components are prepared from phytanyl hemisuccinate, which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit. The syntheses of analogous substances in which the ester links are replaced by amide and by ether links are also described.https://doi.org/10.1071/CH01111
© CSIRO 2001
