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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Mannich Reaction Product of Quinolin-8-ol (Oxine) and its Antibacterial Activity

Shaheen Faizi, Bina Shaheen Siddiqui, Rubeena Saleem, Farzana Akhtar, Khursheed Ali Khan, Shakeel Ahmed Khan, Salimuzzaman Siddiqui, Masood Parvez and M. Iqbal Choudhary

Australian Journal of Chemistry 50(8) 861 - 864
Published: 1997

Abstract

Quinolin-8-ol (1) on reaction with 2,6-dichloroaniline and m-nitrobenzaldehyde afforded 7-(α-hydroxy- m-nitrobenzyl)quinolin-8-ol (2), which is an unusual Mannich reaction product. The structure of (2) was determined by spectroscopic and single-crystal X-ray diffraction studies. Preliminary antimicrobial screening showed that (1) and (2) have activity against a large number of Gram-positive and Gram-negative bacteria.

https://doi.org/10.1071/C96056

© CSIRO 1997

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