Immunohistochemical Demonstration of Somatostatin in the Pancreas of Fetal and Adult Sheep

Abstract

Pancreatic cells immunoreactive with rabbit anti-somatostatin serum were demonstrated in fetal and adult sheep by immunofluorescence histochemistry. Our observations provide evidence that in the sheep the pancreas is a major site of production of the hormone. It is suggested that the hormone may be important in modulating intra- and extra-islet function.