The Metabolism of Tritiated Testosterone by a Wether

Abstract

An experiment to study the metabolism of exogenous testosterone and the formation of tissue residues in a wether is described. Testosterone labelled with tritium by a catalytic process was injected intramuscularly. Rapid metabolism resulted in the excretion of 74'5% of the injected radioactivity in 4 days and complete elimination (101, 4%) in 31 days, of which the urine accounted for 59· 6%, faeces 41'0%, and expired air 0'8%.