The Catalytic Effect of Molybdate on the Breakdown of Phosphocreatine

Abstract

The hydrolysis of phosphocreatine in O.lN HCl at 37 and 65'C. yields,as the principal products, creatine and orthophosphoric acid. Under theinfluence of molybdate, phosphocreatine in O.lN HCI at 37 and 65'C. breaksdown into creatinine, creatine, and orthophosphoric acid. The relative proportionsof the two former compounds are a function of the molybdate concentration.Increase of pH leads to a progressive reduction in this effect of molybdate,which apparently depends upon the degree of ionization.