Leveraging existing data to improve antimicrobial resistance-related mortality estimates for Australia
Teresa M. Wozniak A B * , Anthony Nguyen A , Norm Good A and Geoffrey W. Coombs CA
B
C
Abstract
Antimicrobial resistance (AMR) is a global pandemic, however, estimating its burden is a complex process. As a result, many countries rely on global estimates to infer burden within their own setting. With a growing number of recent publications quantifying AMR burden in Australia, and an expansion of surveillance programs, enumerating AMR mortality for Australia is feasible. We aimed to leverage existing published data to assess methodological factors contributing to the considerable variation in AMR-related mortality and provide two reliable estimates of AMR mortality in Australia. This is a necessary step towards generating meaningful measures of AMR burden in Australia.
Keywords: all-cause mortality, antimicrobial resistance, associated mortality, attributable mortality, Australia, burden of disease, epidemiology, mortality.
References
1 Antimicrobial Resistance Collaborators.. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 2022; 399: 629-655.
| Crossref | Google Scholar | PubMed |
2 Dunachie SJ, Day NPJ, Dolecek C. The challenges of estimating the human global burden of disease of antimicrobial resistant bacteria. Curr Opin Microbiol 2020; 57: 95-101.
| Crossref | Google Scholar | PubMed |
3 de Kraker MEA, Lipsitch M. Burden of Antimicrobial Resistance: Compared to What? Epidemiol Rev 2021; 43(1): 53-64.
| Crossref | Google Scholar | PubMed |
6 Wozniak TM, Dyda A, Merlo G, Hall L. Disease burden, associated mortality and economic impact of antimicrobial resistant infections in Australia. Lancet Reg Health West Pac 2022; 27: 100521.
| Crossref | Google Scholar | PubMed |
8 Lee XJ, Stewardson AJ, Worth LJ, Graves N, Wozniak TM. Attributable length of stay, mortality risk and costs of bacterial healthcare-associated infections in Australia: a retrospective case-cohort study. Clin Infect Dis 2020; 72: e506-e514.
| Crossref | Google Scholar | PubMed |
9 Australian Commission on Safety and Quality in Health Care. AURA 2021: fourth Australian report on antimicrobial use and resistance in human health. 2021. Available at https://www.safetyandquality.gov.au/sites/default/files/2021-09/aura_2021_-_report_-_final_accessible_pdf_-_for_web_publication.pdf
10 Australian Commission on Safety and Quality in Health Care. AURA 2017: Second Australian report on antimicrobial use and resistance in human health. 2017. Available at https://www.safetyandquality.gov.au/wp-content/uploads/2018/01/AURA-2017-Second-Australian-report-on-Antimicrobial-Use-and-Resistance-in-human-health.pdf
11 Cassini A, Högberg LD, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis. Lancet Infect Dis 2019; 19(1): 56-66.
| Crossref | Google Scholar | PubMed |
12 Horcajada JP, Montero M, Oliver A, et al. Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections. Clin Microbiol Rev 2019; 32(4):.
| Crossref | Google Scholar | PubMed |
13 Mork RL, Hogan PG, Muenks CE, et al. Longitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated methicillin-resistant S aureus skin and soft tissue infection: a prospective cohort study. Lancet Infect Dis 2020; 20(2): 188-98.
| Crossref | Google Scholar | PubMed |
14 Wozniak TM, Dyda A, Lee X. The Increased Length of Hospital Stay and Mortality Associated With Community-Associated Infections in Australia. Open Forum Infect Dis 2022; 9(5): ofac133.
| Crossref | Google Scholar | PubMed |