Register      Login
Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
Shopping Cart: ( empty )
You are here: Home > Journals > CH > CH13255
RESEARCH FRONT
Contents Vol 66(12)

Fragment-based Drug Discovery: the Shape of Things to Come

Martin J. Drysdale
+ Author Affiliations
- Author Affiliations

Drug Discovery Programme, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK. Email: m.drysdale@beatson.gla.ac.uk

Australian Journal of Chemistry 66(12) 1544-1549 https://doi.org/10.1071/CH13255
Submitted: 15 May 2013  Accepted: 28 June 2013   Published: 5 August 2013

Abstract

Fragment-Based Drug Discovery (FBDD) is here to stay. Validated as a technology with the delivery of Zelboraf (Vemurafenib) for the treatment of mutant B-RafV600E melanoma, it has become embedded within the pharmaceutical and biotechnology industries. FBDD has delivered clinical development candidates for a broad range of targets including some of the most challenging cases such as β-secretase (BACE1) and protein–protein interactions. But the best is surely still to come.


References

[1]  D. J. Payne, M. N. Gwynn, D. J. Holmes, D. L. Pompliano, Nat. Rev. Drug Discov. 2007, 6, 29.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD28XhtlGktbfM&md5=50fe5026121c8a366d8f8707f1fb2a9aCAS | 17159923PubMed |

[2]  W. P. Jencks, Proc. Natl. Acad. Sci. USA 1981, 78, 4046.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaL3MXlvVamtbo%3D&md5=7b4bca0b6765876e8a6ac5d6b35a72c0CAS | 16593049PubMed |

[3]  S. B. Shuker, P. J. Hajduk, R. P. Meadows, S. W. Fesik, Science 1996, 274, 1531.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK28Xnt1ansLs%3D&md5=a7d3fc936fa7c01148ae7c3b0e3964ceCAS | 8929414PubMed |

[4]  R. E. Hubbard, B. Davis, I. Chen, M. J. Drysdale, Curr. Top. Med. Chem. 2007, 7, 1568.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhsVOrur7J&md5=3e8f3cd2bd8118d20697af8a48729438CAS | 17979768PubMed |

[5]  J. B. Jordan, L. Poppe, X. Xia, A. C. Cheng, Y. Sun, K. Michelsen, H. Eastwood, P. D. Schnier, T. Nixey, W. Zhong, J. Med. Chem. 2012, 55, 678.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1SrtLfJ&md5=d0d84cb025f67e92db4e6ecf85605386CAS | 22165820PubMed |

[6]  C. W. Murray, T. L. Blundell, Curr. Opin. Struct. Biol. 2010, 20, 497.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtVKhtLvF&md5=495ad9231ead36f8e2d201c92f57586fCAS | 20471246PubMed |

[7]  J. Tsai, J. T. Lee, W. Wang, J. Zhang, H. Cho, S. Mamo, R. Bremer, S. Gillette, J. Kong, N. K. Haass, K. Sproesser, L. Li, K. S. Smalley, D. Fong, Y. L. Zhu, A. Marimuthu, H. Nguyen, B. Lam, J. Liu, I. Cheung, J. Rice, Y. Suzuki, C. Luu, C. Settachatgul, R. Shellooe, J. Cantwell, S. H. Kim, J. Schlessinger, K. Y. Zhang, B. L. West, B. Powell, G. Habets, C. Zhang, P. N. Ibrahim, P. Hirth, D. R. Artis, M. Herlyn, G. Bollag, Proc. Natl. Acad. Sci. USA 2008, 105, 3041.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXjtVSitrk%3D&md5=f55aba0c859344d2b26ba6a77cc3eefeCAS | 18287029PubMed |

[8]  I. Navratilova, A. L. Hopkins, ACS Med. Chem. Lett. 2010, 1, 44.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhs1agtbk%3D&md5=c3819245ffe4db3f1c4eeda849222c27CAS |

[9]  D. E. Scott, M. T. Ehebauer, T. Pukala, M. Marsh, T. L. Blundell, A. R. Venkitaraman, C. Abell, M. Hyvonen, ChemBioChem 2013, 14, 332.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXht1Gks7Y%3D&md5=a49226241a8480883a6d20ef19050365CAS | 23344974PubMed |

[10]  D. A. Erlanson, J. A. Wells, Annu. Rev. Biophys. Biomol. Struct. 2004, 33, 199.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2cXltlKktrY%3D&md5=c1bb2dfb6828b73ad287245c35a5fb98CAS | 15139811PubMed |

[11]  P. P. Seth, A. Miyaji, E. A. Jefferson, K. A. Sannes-Lowery, S. A. Osgood, S. S. Propp, R. Ranken, C. Massire, R. Sampath, D. J. Ecker, E. E. Swayze, R. H. Griffey, J. Med. Chem. 2005, 48, 7099.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXhtFahs7zN&md5=338d06b3ae637b1ee0c772ca2c0bdcd2CAS | 16279767PubMed |

[12]  H. J. Maple, R. A. Garlish, L. Rigau-Roca, J. Porter, I. Whitcombe, C. E. Prosser, J. Kennedy, A. J. Henry, R. J. Taylor, M. P. Crump, J. Crosby, J. Med. Chem. 2012, 55, 837.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhs1SmtbvN&md5=db0ac3350c45afd20eadb1e770f653d9CAS | 22148839PubMed |

[13]  C. Austin, S. N. Pettit, S. K. Magnolo, J. Sanvoisin, W.-J. Chen, S. P. Wood, L. D. Freeman, R. J. Pengelly, D. E. Hughes, J. Biomol. Screen. 2012, 17, 868.
         | Crossref | GoogleScholarGoogle Scholar | 22573733PubMed |

[14]  S. A. I. Seidel, C. J. Wienken, S. Geissler, M. Jerabek-Willemsen, S. Duhr, A. Reiter, D. Trauner, D. Braun, P. Baaske, Angew. Chem. Int. Ed. 2012, 51, 10656.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xhtl2qu73F&md5=f55d62b85057bc09b74632d3a7fdc9abCAS |

[15]  M.-D. Duong-Thi, E. Meiby, M. Bergström, T. Fex, R. Isaksson, S. Ohlson, Anal. Biochem. 2011, 414, 138.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXlvVCiu7Y%3D&md5=5bb41aa674bc12873b740936efb6f7bcCAS | 21352794PubMed |

[16]  E. Meiby, S. Knapp, J. M. Elkins, S. Ohlson, Anal. Bioanal. Chem. 2012, 404, 2417.
         | 1:CAS:528:DC%2BC38Xht1Cgtb7N&md5=97a47b5d136210d96908a61e27e55e7aCAS | 22918538PubMed |

[17]  G. Bollag, P. Hirth, J. Tsai, J. Zhang, P. N. Ibrahim, H. Cho, W. Spevak, C. Zhang, Y. Zhang, G. Habets, E. A. Burton, B. Wong, G. Tsang, B. L. West, B. Powell, R. Shellooe, A. Marimuthu, H. Nguyen, K. Y. Zhang, D. R. Artis, J. Schlessinger, F. Su, B. Higgins, R. Iyer, K. D’Andrea, A. Koehler, M. Stumm, P. S. Lin, R. J. Lee, J. Grippo, I. Puzanov, K. B. Kim, A. Ribas, G. A. McArthur, J. A. Sosman, P. B. Chapman, K. T. Flaherty, X. Xu, K. L. Nathanson, K. Nolop, Nature 2010, 467, 596.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXht1ajtbfK&md5=7013e9a231333a70eb593597f24bf61eCAS | 20823850PubMed |

[18]  D. Erlanson, Fragments in the clinic: 2013 edition. Available at: http://practicalfragments.blogspot.com/2013/01/fragments-in-clinic-2013-edition.html (verified July 2013).

[19]  P. A. Brough, W. Aherne, X. Barril, J. Borgognoni, K. Boxall, J. E. Cansfield, K.-M. J. Cheung, I. Collins, N. G. M. Davies, M. J. Drysdale, B. Dymock, S. A. Eccles, H. Finch, A. Fink, A. Hayes, R. Howes, R. E. Hubbard, K. James, A. M. Jordan, A. Lockie, V. Martins, A. Massey, T. P. Matthews, E. McDonald, C. J. Northfield, L. H. Pearl, C. Prodromou, S. Ray, F. I. Raynaud, S. D. Roughley, S. Y. Sharp, A. Surgenor, D. L. Walmsley, P. Webb, M. Wood, P. Workman, L. Wright, J. Med. Chem. 2008, 51, 196.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXhtlWqsL%2FK&md5=a49f7a18a8037ff93cb9266f9929ed37CAS | 18020435PubMed |

[20]  A. J. Woodhead, H. Angove, M. G. Carr, G. Chessari, M. Congreve, J. E. Coyle, J. Cosme, B. Graham, P. J. Day, R. Downham, L. Fazal, R. Feltell, E. Figueroa, M. Frederickson, J. Lewis, R. McMenamin, C. W. Murray, M. A. O’Brien, L. Parra, S. Patel, T. Phillips, D. C. Rees, S. Rich, D.-M. Smith, G. Trewartha, M. Vinkovic, B. Williams, A. J.-A. Woolford, J. Med. Chem. 2010, 53, 5956.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXpsVCitrg%3D&md5=f920d710df96d1d3197c1f5f89ae3f05CAS | 20662534PubMed |

[21]  P. A. Brough, X. Barril, J. Borgognoni, P. Chene, N. G. M. Davies, B. Davis, M. J. Drysdale, B. Dymock, S. A. Eccles, C. Garcia-Echeverria, C. Fromont, A. Hayes, R. E. Hubbard, A. M. Jordan, M. Rugaard Jensen, A. Massey, A. Merrett, A. Padfield, R. Parsons, T. Radimerski, F. I. Raynaud, A. Robertson, S. D. Roughley, J. Schoepfer, H. Simmonite, S. Y. Sharp, A. Surgenor, M. Valenti, S. Walls, P. Webb, M. Wood, P. Workman, L. Wright, J. Med. Chem. 2009, 52, 4794.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXos1ehsbs%3D&md5=45b47bdd78789902f73768250261b504CAS | 19610616PubMed |

[22]  J. R. Huth, C. Park, A. M. Petros, A. R. Kunzer, M. D. Wendt, X. Wang, C. L. Lynch, J. C. Mack, K. M. Swift, R. A. Judge, J. Chen, P. L. Richardson, S. Jin, S. K. Tahir, E. D. Matayoshi, S. A. Dorwin, U. S. Ladror, J. M. Severin, K. A. Walter, D. M. Bartley, S. W. Fesik, S. W. Elmore, P. J. Hajduk, Chem. Biol. Drug Des. 2007, 70, 1.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2sXovFCktrY%3D&md5=b71cf4871a0a94f4763e416a4bf98da8CAS | 17630989PubMed |

[23]  J. J. Barker, O. Barker, R. Boggio, V. Chauhan, R. K. Cheng, V. Corden, S. M. Courtney, N. Edwards, V. M. Falque, F. Fusar, M. Gardiner, E. M. Hamelin, T. Hesterkamp, O. Ichihara, R. S. Jones, O. Mather, C. Mercurio, S. Minucci, C. A. Montalbetti, A. Muller, D. Patel, B. G. Phillips, M. Varasi, M. Whittaker, D. Winkler, C. J. Yarnold, ChemMedChem 2009, 4, 963.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXmslChtbk%3D&md5=fa33f9abf5695c11bb1f6b59cf332b0aCAS | 19301319PubMed |

[24]  J. J. Barker, O. Barker, S. M. Courtney, M. Gardiner, T. Hesterkamp, O. Ichihara, O. Mather, C. A. Montalbetti, A. Muller, M. Varasi, M. Whittaker, C. J. Yarnold, ChemMedChem 2010, 5, 1697.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3cXhtlCkurzI&md5=858a9391126f9b4b042d8a55b433063bCAS | 20665758PubMed |

[25]  S. D. Roughley, R. E. Hubbard, J. Med. Chem. 2011, 54, 3989.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXmsFymurs%3D&md5=d6d8f7be0b4b2e0f4988de1ead900373CAS | 21561141PubMed |

[26]  S. J. Stachel, Drug Dev. Res. 2009, 70, 101.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXkt1Cgtbs%3D&md5=f7e456f6fc3d0a226323f20d4b83af41CAS |

[27]  P. C. May, R. A. Dean, S. L. Lowe, F. Martenyi, S. M. Sheehan, L. N. Boggs, S. A. Monk, B. M. Mathes, D. J. Mergott, B. M. Watson, S. L. Stout, D. E. Timm, E.-s. LaBell, C. R. Gonzales, M. Nakano, S. S. Jhee, M. Yen, L. Ereshefsky, T. D. Lindstrom, D. O. Calligaro, P. J. Cocke, D. G. Hall, S. Friedrich, M. Citron, J. E. Audia, J. Neurosci. 2011, 31, 16507.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFaksL7F&md5=c527c9ea864581c6e305e8766d89dfe1CAS | 22090477PubMed |

[28]  D. F. Wyss, Y.-S. Wang, H. L. Eaton, C. Strickland, J. H. Voigt, Z. Zhu, A. W. Stamford, Top. Curr. Chem. 2012, 317, 83.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xht1ShurvP&md5=8aa4e0ea77971b786f8e91e3e5b07116CAS | 21647837PubMed |

[29]  F. Jeppsson, S. Eketjall, J. Janson, S. Karlstrom, S. Gustavsson, L.-L. Olsson, A.-C. Radesater, B. Ploeger, G. Cebers, K. Kolmodin, B.-M. Swahn, S. von Berg, T. Bueters, J. Falting, J. Biol. Chem. 2012, 287, 41245.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhslGjs7fE&md5=e90c2199182211145b6b3249e7a62a1cCAS | 23048024PubMed |

[30]  A. L. Hopkins, C. R. Groom, A. Alex, Drug Discov. Today 2004, 9, 430.
         | Crossref | GoogleScholarGoogle Scholar | 15109945PubMed |

[31]  T. Oltersdorf, S. W. Elmore, A. R. Shoemaker, R. C. Armstrong, D. J. Augeri, D. J. Augeri, B. A. Belli, M. Bruncko, T. L. Deckwerth, J. Dinges, P. J. Hajduk, M. K. Joseph, S. Kitada, S. J. Korsmeyer, A. R. Kunzer, A. Letai, C. Li, M. J. Mitten, D. G. Nettesheim, S.-C. Ng, P. M. Nimmer, J. M. O’Connor, A. Oleksijew, A. M. Petros, J. C. Reed, W. Shen, S. K. Tahir, C. B. Thompson, K. J. Tomaselli, B. Wang, M. D. Wendt, H. Zhang, S. W. Fesik, S. H. Rosenberg, Nature 2005, 435, 677.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD2MXks1Ogtb0%3D&md5=2549cc0f87e2af7643589481d54108cdCAS | 15902208PubMed |

[32]  C. M. Park, M. Bruncko, J. Adickes, J. Bauch, H. Ding, A. Kunzer, K. C. Marsh, P. Nimmer, A. R. Shoemaker, X. Song, S. K. Tahir, C. Tse, X. Wang, M. D. Wendt, X. Yang, H. Zhang, S. W. Fesik, S. H. Rosenberg, S. W. Elmore, J. Med. Chem. 2008, 51, 6902.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1cXht1WlsbvE&md5=aa34531a6b5abf4a0f44e7fc73104881CAS | 18841882PubMed |

[33]  T. Maurer, L. S. Garrenton, A. Oh, K. Pitts, D. J. Anderson, N. J. Skelton, B. P. Fauber, B. Pan, S. Malek, D. Stokoe, M. J. C. Ludlam, K. K. Bowman, J. Wu, A. M. Giannetti, M. A. Starovasnik, I. Mellman, P. K. Jackson, J. Rudolph, W. Wang, G. Fang, Proc. Natl. Acad. Sci. USA 2012, 109, 5299.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XlslOjsrc%3D&md5=c4a81b1f8c99a7dda7c06843b902daf0CAS | 22431598PubMed |

[34]  Q. Sun, J. P. Burke, J. Phan, M. C. Burns, E. T. Olejniczak, A. G. Waterson, T. Lee, O. W. Rossanese, S. W. Fesik, Angew. Chem. Int. Ed. 2012, 51, 6140.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38Xms1entr4%3D&md5=7d53ea6715972ce65d9c1327673eddcaCAS |

[35]  A. Friberg, D. Vigil, B. Zhao, R. N. Daniels, J. P. Burke, P. M. Garcia-Barrantes, D. Camper, B. A. Chauder, T. Lee, E. T. Olejniczak, S. W. Fesik, J. Med. Chem. 2013, 56, 15.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhvVCjur3J&md5=b04d49108c23077f75bcd8653817ef08CAS | 23244564PubMed |

[36]  J. D. Patrone, J. P. Kennedy, A. O. Frank, M. D. Feldkamp, B. Vangamudi, N. F. Pelz, O. W. Rossanese, A. G. Waterson, W. J. Chazin, S. W. Fesik, ACS Med. Chem. Lett. 2013, 4, 601.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXmvVymt7k%3D&md5=d600dc218fd4cf5aed56341eb2f3632aCAS |

[37]  J. F. Bower, A. Pannifer, Curr. Pharm. Des. 2012, 18, 4685.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsF2gu7fE&md5=c48e76c6526ee5746f19087ff30094b3CAS | 22650253PubMed |

[38]  F. Lovering, J. Bikker, C. Humblet, J. Med. Chem. 2009, 52, 6752.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXht1KjtLvN&md5=1be92b1310beca07aef8d83f3d16b003CAS | 19827778PubMed |

[39]  F. Lovering, Med. Chem. Comm. 2013, 4, 515.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXjtFShtL0%3D&md5=d777123f44f0e75ed4388c2ec07ecfaeCAS |

[40]  T. J. Ritchie, S. J. F. Macdonald, Drug Discov. Today 2009, 14, 1011.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD1MXhtlCgt7nP&md5=f2cef4e1fe0f13a33b27b1f9a43236ecCAS | 19729075PubMed |

[41]  T. J. Ritchie, S. J. F. Macdonald, R. J. Young, S. D. Pickett, Drug Discov. Today 2011, 16, 1011.

[42]  P. W. Kenny, C. A. Montanari, J. Comput. Aided Mol. Des. 2013, 27, 1.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXis1SrtbY%3D&md5=47b319ffa10349529b9756dd8d86b6aeCAS | 23306465PubMed |

[43]  W. H. B. Sauer, M. K. Schwarz, J. Chem. Inf. Comput. Sci. 2003, 43, 987.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BD3sXhvF2muro%3D&md5=2385f00ef0f956ecdd3cd882a4b3d1e4CAS |

[44]  ZINC ‘InMan’ subset. Available at: http://zinc.docking.org/subsets/zim (verified July 2013).

[45]  X. Q. Lewell, D. B. Judd, S. P. Watson, M. M. Hann, J. Chem. Inf. Comput. Sci. 1998, 38, 511.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DyaK1cXis1yrtbg%3D&md5=573bb4d9fd17b62225c58dcbf55bda86CAS | 9611787PubMed |

[46]  3DFrag. Available at: http://www.3dfrag.org/ (verified July 2013).

[47]  K. Birchall, J. Bower, P. Brennan, N. Brown, T. Chapman, M. J. Drysdale, I. Gilbert, S. Hoelder, A. Jordan, S. V. Ley, A. Merritt, D. Miller, A. D. Morley, A. Pugliese, M. Swarbrick, P. G. Wyatt, Drug Discovery Today 2013, in press.
         | 23906694PubMed |

[48]  J. A. Christopher, J. Brown, A. S. Dore, J. C. Errey, M. Koglin, F. H. Marshall, D. G. Myszka, R. L. Rich, C. G. Tate, B. Tehan, T. Warne, M. Congreve, J. Med. Chem. 2013, 56, 3446.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3sXktlekt7o%3D&md5=b9f227d12efaa80277e547df6a87a28bCAS | 23517028PubMed |

[49]  C.-w. Chung, A. W. Dean, J. M. Woolven, P. Bamborough, J. Med. Chem. 2012, 55, 576.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFKktrnN&md5=68cdb40cddf864c0d8872c8106032dedCAS | 22136404PubMed |

[50]  P. Bamborough, H. Diallo, J. D. Goodacre, L. Gordon, A. Lewis, J. T. Seal, D. M. Wilson, M. D. Woodrow, C.-w. Chung, J. Med. Chem. 2012, 55, 587.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC3MXhsFKktrfF&md5=610bb445a709194c2e7ed3b257a2b152CAS | 22136469PubMed |

[51]  P. V. Fish, P. Filippakopoulos, G. Bish, P. E. Brennan, M. E. Bunnage, A. S. Cook, O. Federov, B. S. Gerstenberger, H. Jones, S. Knapp, B. Marsden, K. Nocka, D. R. Owen, M. Philpott, S. Picaud, M. J. Primiano, M. J. Ralph, N. Sciammetta, J. D. Trzupek, J. Med. Chem. 2012, 55, 9831.
         | Crossref | GoogleScholarGoogle Scholar | 1:CAS:528:DC%2BC38XhsFGmtLnE&md5=f66f6bdbb5a2679a1bb5049d722b5e2cCAS | 23095041PubMed |