Fragment Screening by Native State Mass Spectrometry

Sally-Ann Poulsen

doi:10.1071/CH13190

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Fragment Screening by Native State Mass Spectrometry

Sally-Ann Poulsen

+ Author Affiliations

- Author Affiliations

Eskitis Institute for Drug Discovery, Griffith University, Brisbane, Qld 4111, Australia. Email: s.poulsen@griffith.edu.au

Sally-Ann Poulsen received her Ph.D. in medicinal chemistry in 1996. She was awarded a Howard Florey Research Fellowship at the University of Cambridge in 1998, an ARC QEII Fellowship in 2000 and an ARC Future Fellowship in 2012. She is currently Associate Professor at the Eskitis Institute for Drug Discovery, Griffith University. Her research encompasses medicinal chemistry and chemical biology. This research harnesses both the chemistry of small molecules and methods such as mass spectrometry to detect small molecules to address human disease.

Australian Journal of Chemistry 66(12) 1495-1501 https://doi.org/10.1071/CH13190
Submitted: 19 April 2013 Accepted: 22 May 2013 Published: 18 June 2013

Abstract

Native state mass spectrometry (MS) has been recognised as a rapid, sensitive, and high throughput method to directly investigate protein-ligand interactions for some time, however there are few examples reporting this approach as a screening method to identify relevant protein–fragment interactions in fragment-based drug discovery (FBDD). In this paper an overview of native state MS will be presented, highlighting the attractive properties of this method within the context of fragment screening applications. A summary of published examples using MS for fragment screening will be described and reflection on the outlook for the future adoption and implementation of native state MS as a complementary fragment screening method will be presented.

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Fragment Screening by Native State Mass Spectrometry

Abstract

References

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