Synthesis of MUC1 Peptide and Glycopeptide Dendrimers
Candy K. Y. Chun A and Richard J. Payne A BA School of Chemistry, The University of Sydney, NSW 2006, Australia.
B Corresponding author. Email: payne@chem.usyd.edu.au
Australian Journal of Chemistry 62(10) 1339-1343 https://doi.org/10.1071/CH09282
Submitted: 12 May 2009 Accepted: 19 June 2009 Published: 13 October 2009
Abstract
Several dendrimers possessing multiple copies of peptides and glycopeptides belonging to the MUC1 eicosapeptide tandem repeat sequence have been prepared. Fmoc-strategy solid-phase peptide synthesis was used to construct the peptides and glycopeptides, which were conjugated to suitably functionalized dendrimer cores using the copper-catalyzed azide-alkyne cycloaddition reaction to produce multivalent peptide and glycopeptide dendrimers.
Acknowledgements
We would like to thank the Australian Research Council for funding and Yves Hsieh for assistance with MALDI-TOF mass spectrometry.
[1]
A. Varki,
Glycobiology 1993, 3, 97.
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