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RESEARCH ARTICLE
Contents Vol 51(1)

Treatment with the immunocontraceptive vaccine, GonaCon, induces temporary fertility control in free-ranging prairie dog populations in Colorado, USA

Aaron B. Shiels https://orcid.org/0000-0002-6774-4560 A * , Jackson Runte B , Emily W. Ruell A , Douglas C. Eckery A , Gary W. Witmer A and Daniel J. Salkeld B
+ Author Affiliations
- Author Affiliations

A USDA, APHIS Wildlife Services, National Wildlife Research Center, 4101 LaPorte Avenue, Fort Collins, CO 80521, USA.

B Department of Biology, Colorado State University, 251 West Pitkin Street, Fort Collins, CO 80521, USA.

* Correspondence to: aaron.b.shiels@usda.gov

Handling Editor: Stephanie Boyles Griffin

Wildlife Research 51, WR22135 https://doi.org/10.1071/WR22135
Submitted: 21 September 2022  Accepted: 27 May 2023  Published: 13 July 2023

© 2024 The Author(s) (or their employer(s)). Published by CSIRO Publishing

Abstract

Context

Prairie dogs (Cynomys spp.) are rodents enjoyed by some humans; yet, they cause crop and property damage, and carry zoonotic disease. Non-lethal control of prairie dogs is of interest in urban/suburban settings. The injectable immunocontraceptive vaccine GonaCon (active ingredient is gonadotropin-releasing hormone [GnRH]) has been shown to be effective at reducing fertility in equine and deer, and is a US EPA-registered vaccine for use in these ungulate species.

Aims

To conduct a replicated field study to test efficacy of GonaCon in black-tailed prairie dogs (C. ludovicianus), and if found to be efficacious, to help facilitate the EPA registration of this product for prairie dog management in urban/suburban areas.

Methods

Prairie dogs were live-trapped in October–December 2018 in three treatment and three control sites. Every captured female ≥660 g was injected with 0.4 mL of either GonaCon (0.032% w/w GnRH) at treatment sites or a sham vaccine (absent of GnRH) at control sites. Juveniles and adults were counted at all six sites to establish juvenile:adult (ratio) and juvenile density in May–June 2019 (determining initial GonaCon effectiveness) and 2020 (determining persistence of contraception).

Key results

In 2019, the juvenile:adult ratio was significantly reduced (P = 0.0022) in GonaCon (mean ± s.e.: 0.23 ± 0.01) relative to the sham (1.10 ± 0.58) sites. Juvenile density was three times greater in sham than GonaCon sites. In 2020, GonaCon sites produced equal offspring to nearby sham sites.

Conclusions

GonaCon is highly effective during the first year (2019) but not in the second year (2020) if only a small area (0.6–2.8 ha) or small proportion of females in a colony is treated, such as was undertaken in this study.

Implications

In 2022, GonaCon−Prairie Dogs was EPA-registered. Treating whole colonies of prairie dogs at once is favoured; yet, if small or partial colony treatment is desired, then annual GonaCon treatment may be needed.

Keywords: animal population management, black-tailed prairie dogs, contraceptive injection, Cynomys ludovicianus, human-wildlife conflict, non-lethal fertility control, rodent vaccine, trapping surveys, visual counts.

References

Andelt WF, Hopper SN (2016) ‘Managing prairie dogs.’ Bulletin Number 6.506. (Colorado State University Cooperative Extension: Fort Collins, CO, USA)

Baker DL, Powers JG, Ransom JI, McCann BE, Oehler MW, Bruemmer JE, Galloway NL, Eckery DC, Nett TM (2018) Reimmunization increases contraceptive effectiveness of gonadotropin-releasing hormone vaccine (GonaCon-Equine) in free-ranging horses (Equus caballus): limitations and side effects. PLoS ONE 13(7), e0201570.
| Crossref | Google Scholar |

Garrett MG, Franklin WL (1988) Behavioral ecology of dispersal in the black-tailed prairie dog. Journal of Mammalogy 69, 236-250.
| Crossref | Google Scholar |

Hoogland JL (1981) The evolution of coloniality in white-tailed and black-tailed prairie dogs (Sciuridae: Cynomys leucurus and C. ludovicianus). Ecology 62, 252-272.
| Crossref | Google Scholar |

Hoogland JL (1995) ‘The black-tailed prairie dog: social life of a burrowing mammal.’ (University of Chicago Press: Chicago, Il, USA)

Hoogland JL (2002) ‘Conservation of the black-tailed prairie dog: saving North America’s western grassland.’ (Island Press: Washington, DC, USA)

Hoogland JL (2003) Sexual dimorphism of prairie dogs. Journal of Mammalogy 84, 1254-1266.
| Crossref | Google Scholar |

Hygnstrom SE, VerCauteren KC (2000) Cost-effectiveness of five burrow fumigants for managing black-tailed prairie dogs. International Biodeterioration & Biodegradation 45, 159-168.
| Crossref | Google Scholar |

Hygnstrom SE, Virchow DR (1994) Prairie dogs. In ‘Prevention and control of wildlife damage’. (Eds SE Hygnstrom, GA Larson, RM Timm) pp. B85–B96. (University of Nebraska Cooperative Extension: Lincoln, NE, USA)

Koprowski JL (2002) Handling tree squirrels with a safe and efficient restraint. Wildlife Society Bulletin 30, 101-103.
| Google Scholar |

Lambert MS, Massei G, Yoder CA, Cowan DP (2010) An evaluation of Diazacon as a potential contraceptive in non-native rose-ringed parakeets. Journal of Wildlife Management 74, 573-581.
| Crossref | Google Scholar |

Menkens GE, Jr, Biggins DE, Anderson SH (1990) Visual counts as an index of white-tailed prairie dog density. Wildlife Society Bulletin 18, 290-296.
| Google Scholar |

Miller LA, Fagerstone KA, Eckery DC (2013) Twenty years of immunocontraceptive research: lessons learned. Journal of Zoo and Wildlife Medicine 44, S84-S96.
| Crossref | Google Scholar |

Salkeld DJ, Stapp P, Tripp DW, Gage KL, Lowell J, Webb CT, Brinkerhoff RJ, Antolin MF (2016) Ecological traits driving the outbreaks and emergence of zoonotic pathogens. BioScience 66, 118-129.
| Crossref | Google Scholar |

Severson KE, Plumb GE (1998) Comparison of methods to estimate population densities of black-tailed prairie dogs. Wildlife Society Bulletin 26, 859-866.
| Google Scholar |

Shiels AB, Fischer JW, Spock D, Allira M (2022) Improving efficiency of prairie dog surveys by using a small copter drone. In ‘Proceedings of the 30th Vertebrate Pest Conference’. Paper No. 21. (Ed. DM Woods) p. 7. (University of California: Davis, CA, USA)

Tripp DW, Rocke TE, Runge JP, Abbott RC, Miller MW (2017) Burrow dusting or oral vaccination prevents plague-associated prairie dog colony collapse. EcoHealth 14, 451-462.
| Crossref | Google Scholar |

Vercauteren KC, Dolbeer RA, Gese EM (2010) Chapter 34. Identification and management of wildlife damage. In ‘The wildlife techniques manual’. (Ed. NJ Silvy) pp. 232–269. (John Hopkins University Press: Baltimore, MD, USA)

Witmer GW, Fagerstone KA (2003) The use of toxicants in black-tailed prairie dog management: an overview. In ‘Proceedings of the 10th Wildlife Damage Management Conference’. USDA National Wildlife Research Center – Staff Publication 293. (Eds KA Fagerstone, GW Witmer) pp. 359–369. (USDA National Wildlife Research Center: Fort Collins, CO, USA)

Witmer GW, Vercauteren KC, Manci K, Dees D (2000) Urban-suburban prairie dog management: opportunities and challenges. In ‘Proceedings of the 19th Vertebrate Pest Conference’. (Eds TP Salmon, AC Crab) pp. 439–444. (University of California: Davis, CA, USA)

Witmer G, Gionfriddo J, Pipas M (2008) Evaluation of physical barriers to prevent prairie dog colony expansion. Human–Wildlife Conflicts 2, 206-211.
| Google Scholar |

Yoder CA (2011) Field efficacy of GonaConTM for black-tailed prairie dogs. Unpublished report QA-1383. p. 241. National Wildlife Research Center, Fort Collins, CO, USA.

Yoder CA, Miller LA (2010) Effect of GonaCon™ vaccine on black-tailed prairie dogs: immune response and health effects. Vaccine 29, 233-239.
| Crossref | Google Scholar |

Yoder CA, Miller LA, Fagerstone KA (2008) Population modeling of prairie dog contraception as a management tool. In ‘Proceedings of the 23rd Vertebrate Pest Conference’. (Eds RM Timm, MB Madon) pp. 229–234. (University of California: Davis, CA, USA)

Yoder CA, Mauldin RE, Gionfriddo JP, Crane KA, Goldade DA, Engeman RM (2016) DiazaCon reduces black-tailed prairie dog reproduction in Colorado. Wildlife Research 43, 655-661.
| Crossref | Google Scholar |