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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

2-Imino-1,3,4-thiadiazole Derivatives of GABA as GABAA Antagonists

RD Allan, C Apostopoulos and JA Richardson

Australian Journal of Chemistry 43(10) 1767 - 1772
Published: 1990

Abstract

New heterocyclic derivatives of GABA, with a GABA moiety on the 3 position of a 2-imino-1,3,4-thiadiazole ring, have been readily prepared by alkylation of 2-amino-5-aryl-1,3,4-thiadiazoles in dimethylformamide. They are active as GABAA antagonists, inhibiting the action of GABA on the guinea-pig ileum about 5 times less potently than bicuculline.

https://doi.org/10.1071/CH9901767

© CSIRO 1990

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