Studies of Australian soft corals. XXXIII. New cembranoid diterpenes from a Lobophytum species

Abstract

The isolation of two new cembranoid diterpenes, (14S,1E,3E,7E)-14-acetoxy-11,12-epoxycembra-1,3,7-triene and the corresponding 14-alcohol, is reported from the soft coral Lobophytum sp. A minor component in the extract (3S,4S,1lS,12S,1E,7E)-3,4:11,12-bisepoxycembra-1,7-diene was identified but may be artefactual as it is the sole product of the aerial oxidation of the major metabolite(11S,12S,1 E,3E,7E)-11,12-epoxycembra-1,3,7-triene. Further examples of stereospecific epoxidationsare reported.