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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

The glutarimide antibiotic 9-methylstreptimidone: Structure, biogenesis and biological activity

MS Allen, AM Becker and RW Rickards

Australian Journal of Chemistry 29(3) 673 - 679
Published: 1976

Abstract

The antibiotic responsible for the high antiyeast and antifungal activity of a streptomycete fermentation is shown to be the 9-methyl derivative (1) of streptimidone (2). The conjugated diene system in (1) is assigned the 6E,8Z stereochemistry. Evidence is presented for the biogenetic origin of the 9-methyl group in this streptimidone homologue, and its antifungal activity is compared with that of streptimidone and other fungicides.

https://doi.org/10.1071/CH9760673

© CSIRO 1976

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