The Stereochemistry of Aromadendrene, Globulol, and Ledol

Abstract

The conversion of aromadendrene, obtained from a variety of essential oils or by dehydration of globulol, to apoaromadendrone has been studied, together with the further degradation of apoaromadendrone. The reaction of apoaromadendrone with methyl magnesium iodide has afforded globulol and epiglobulol. From the reactions of these compounds, structures are proposed for aromadendrene (I), apoaromadendrone (II), globulol (III), epiglobulol (IV), and ledol (V).