A Sensitive Catalytic Wave Formed by Electrochemical Reduction of Morin in the Presence of an Oxidant KIO3
Sikun Cheng A E , Yanhua Dong B , Yayan Wu B , Junfeng Song C E and Chuan Zhao D EA Department of Medicinal Chemistry, School of Pharmacy, the Fourth Military Medical University, Xi’an, 710032, China.
B The Key Laboratory of Biomedical Information Engineering, Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, 710049, China.
C Institute of Analytical Science, Northwest University, Xi’an, 710069, China.
D School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
E Corresponding authors. Email: skcheng@fmmu.edu.cn; songjunf@nwu.edu.cn; chuan.zhao@unsw.edu.au
Australian Journal of Chemistry 67(4) 620-625 https://doi.org/10.1071/CH13484
Submitted: 12 September 2013 Accepted: 28 October 2013 Published: 21 November 2013
Abstract
The investigation of the electrogenerated free radical of morin reacting with an oxidant is helpful in understanding its antioxidant pharmacology. In phosphate buffer (pH 5.6 ± 0.1), the reduction of morin proceeds with a one-electron transfer of the C=O double bond into a free radical intermediate, which then delivers the final primary alcohol via a one-electron reduction. When an oxidant KIO3 is present, the free radical intermediate of morin is oxidized to regenerate the original ‘C=O’ bond. Further reduction processes are effectively inhibited, resulting in a sensitive catalytic peak, with the peak current enhanced 70 times.
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