Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

Yousef M. Hamdan; Shitao Fu; Xiangmei Jiang; Yinhua Cheng; Kaixun Huang; Kaichao Yu

doi:10.1071/CH07315

RESEARCH ARTICLE

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Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

Yousef M. Hamdan ^A ^B , Shitao Fu ^A ^B , Xiangmei Jiang ^A , Yinhua Cheng ^A , Kaixun Huang ^A and Kaichao Yu ^A ^C

+ Author Affiliations

- Author Affiliations

^A Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Department of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

^B These authors contributed equally to this work.

^C Corresponding author. Email: yukc@163.com

Australian Journal of Chemistry 61(10) 762-767 https://doi.org/10.1071/CH07315
Submitted: 6 September 2007 Accepted: 7 August 2008 Published: 6 October 2008

Abstract

2-Octylsuccinic acid and its copolyanhydrides with sebacic acid have been synthesized by melt polycondensation, and were characterized by Fourier transform infrared spectroscopy, ¹H NMR, gel permeation chromatography, differential scanning calorimetry, and thermal gravimetric analysis. In vitro studies showed that all copolymers are degradable in phosphate buffer at 37°C. The release profiles of the hydrophilic model drug ciprofloxacin hydrochloride follow first-order release kinetics.

Acknowledgements

The authors thank the National Natural Science Foundation of China (No. 20675033; No. 20275011) and the Natural Science Foundation of Hubei Province (No. 2002AB051) for financial support. Testing assistance from the Testing Centre of Huazhong University of Science and Technology is gratefully acknowledged.

References

Synthesis, Characterization, and Properties of Copolyanhydrides Based on 2-Octylsuccinic Acid and Sebacic Acid

Abstract

Acknowledgements

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