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Australian Journal of Chemistry Australian Journal of Chemistry Society
An international journal for chemical science
RESEARCH ARTICLE

Preparation of the Central Tryptophan Moiety of the Celogentin/Moroidin Family of Anti-Mitotic Cyclic Peptides

Alexander K. L. Yuen A , Katrina A. Jolliffe A and Craig A. Hutton B C
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- Author Affiliations

A School of Chemistry, University of Sydney, Sydney NSW 2006, Australia.

B School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne VIC 3010, Australia.

C Corresponding author. Email: chutton@unimelb.edu.au

Australian Journal of Chemistry 59(11) 819-826 https://doi.org/10.1071/CH06324
Submitted: 1 September 2006  Accepted: 2 October 2006   Published: 17 November 2006

Abstract

The central functionalized tryptophan core of the celogentin/moroidin family of cyclic peptides has been prepared. The strategy incorporates a novel preparation of 4-iodobenzaldehyde and employs a Larock annulation as the key step.


Acknowledgment

This work was supported by the Australian Research Council (DP0208190).


References


[1]   C. T.-W. Leung, D. H. Williams, J. C. J. Barna, S. Foti, P. B. Oerlichs, Tetrahedron 1986, 42,  3333.
        | Crossref |  GoogleScholarGoogle Scholar |  
         
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
         
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  
        | Crossref |  GoogleScholarGoogle Scholar |  open url image1

[25]   D. Kaegi, M. Schlageter, E. Widmer, Eur. Pat. 0280975 1988.